Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequestration in P-bodies sustains myeloid leukemia [RNA-seq]

ABSTRACT: RNA sequestration in P-bodies sustains myeloid leukemia [RNA-seq]

PROVIDER: PRJNA932340 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23362400_1.fastq.gz	Fastqsanger.gz
	SRR23362400_2.fastq.gz	Fastqsanger.gz
	SRR23362401_1.fastq.gz	Fastqsanger.gz
	SRR23362401_2.fastq.gz	Fastqsanger.gz
	SRR23362402_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 64

Similar Datasets

RNA sequestration in P-bodies sustains myeloid leukemia

Project description:RNA sequestration in P-bodies sustains myeloid leukemia

| PRJNA932804 | ENA

RNA sequestration in P-bodies sustains myeloid leukaemia

Project description:RNA sequestration in P-bodies sustains myeloid leukaemia

| PRJNA931996 | ENA

RNA sequestration in P-bodies sustains myeloid leukaemia

Project description:RNA sequestration in P-bodies sustains myeloid leukaemia

| PRJNA1084006 | ENA

RNA sequestration in P-bodies sustains myeloid leukemia [HSPC_RNAseq]

Project description:RNA sequestration in P-bodies sustains myeloid leukemia [HSPC_RNAseq]

| PRJNA1148202 | ENA

RNA sequestration in P-bodies sustains myeloid leukemia [ATAC-seq]

Project description:RNA sequestration in P-bodies sustains myeloid leukemia [ATAC-seq]

| PRJNA932338 | ENA

RNA sequestration in P-bodies sustains myeloid leukemia [small RNA-seq]

Project description:RNA sequestration in P-bodies sustains myeloid leukemia [small RNA-seq]

| PRJNA932803 | ENA

RNA sequestration in P-bodies sustains myeloid leukemia [P-body-seq]

Project description:RNA sequestration in P-bodies sustains myeloid leukemia [P-body-seq]

| PRJNA932348 | ENA

RNA sequestration in P-bodies sustains myeloid leukaemia

Project description:Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide CRISPR screens in normal and malignant haematopoietic progenitors. We found that leukaemia cells harbour aberrantly elevated numbers of P-bodies and show that P-body assembly is crucial for initiation and maintenance of AML. Notably, P-body loss had little effect upon homoeostatic haematopoiesis but impacted regenerative haematopoiesis. Molecular characterization of P-bodies purified from human AML cells unveiled their critical role in sequestering messenger RNAs encoding potent tumour suppressors from the translational machinery. P-body dissolution promoted translation of these mRNAs, which in turn rewired gene expression and chromatin architecture in leukaemia cells. Collectively, our findings highlight the contrasting and unique roles of RNA sequestration in P-bodies during tissue homoeostasis and oncogenesis. These insights open potential avenues for understanding myeloid leukaemia and potential therapeutic interventions.

2024-08-08 | GSE260919 | GEO