Project description:Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. There is increasing evidence that homeostasis of the ocular surface is impacted by the intestinal microbiome. We are interested in investigating the potential role of microbially produced small molecules in mediating the interaction between the intestinal microbiota and the ocular surface. One such molecule is butyrate, a short-chain fatty acid (SCFA) produced by certain members of the gut microbiota through fermentation of dietary fiber. We have shown that oral administration of tributyrin, a prodrug form of butyrate, is protective of the ocular surface in mice undergoing desiccating stress. To gain insight into the mechanism, we analyzed gene expression in conjunctival tissue from mice treated with either tributyrgn or vehicle control.
2022-02-07 | GSE195578 | GEO
Project description:Ocular Surface Microbiome and Rhythms
| PRJNA987049 | ENA
Project description:Genetic risk for ocular squamous cell carcinoma in Haflinger horses
| PRJEB26741 | ENA
Project description:Relationship between bacterial ocular surface microbiome and antiviral treatment outcomes for cats with FHV-1 ocular surface disease
