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Vitamin B12 alleviates myocardial ischemia/reperfusion injury

ABSTRACT: Vitamin B12 alleviates myocardial ischemia/reperfusion injury

PROVIDER: PRJNA933927 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23422172_1.fastq.gz	Fastqsanger.gz
	SRR23422172_2.fastq.gz	Fastqsanger.gz
	SRR23422173_1.fastq.gz	Fastqsanger.gz
	SRR23422173_2.fastq.gz	Fastqsanger.gz
	SRR23422174_1.fastq.gz	Fastqsanger.gz

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Vitamin B12 alleviates myocardial ischemia/reperfusion injury

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Project description:Hepatic ischemia-reperfusion injury (IRI) is a common complication occurs during hepatic resection and transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Here, we aim to explore the role of fibroblast growth factor 18 (FGF18) in hepatic IRI. In this work, we find that Hepatic stellate cells (HSCs) secrete FGF18 and alleviates hepatocytes injury. HSCs-specific FGF18 deletion largely aggravates hepatic IRI. Mechanistically, FGF18 treatment reduces the levels of ubiquitin carboxyl-terminal hydrolase 16 (USP16), leading to increased ubiquitination levels of Kelch Like ECH Associated Protein 1 (KEAP1) and the activation of nuclear factor erythroid 2-related factor 2 (Nrf2). Furthermore, USP16 interacts and deubiquitinates KEAP1. More importantly, Nrf2 directly binds to the promoter of USP16 and forms a negative feedback loop with USP16. Collectively, our results show FGF18 alleviates hepatic IRI by USP16/KEAP1/Nrf2 signaling pathway in male mice, suggesting that FGF18 represents a promising therapeutic approach for hepatic IRI.

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Project description:Purpose: The aim of this study is to compare the plasma miRNA profile between mice subject to myocardial ischemia and reperfusion and mice subject to sham operation. Methods: 8 to 10-week old C57BL/6 mice underwent myocardial ischemia and reperfusion (MIR) or Sham operation. Plasma RNA was isolated using Trizol LS reagent 4h post-surgery. NGS cDNA libraries were prepared using Norgen Biotek Small RNA Library Prep Kit. Library quality was validated prior to sequencing on an Illumina NextSeq 500 platform.

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Transcription profiling of rat NRVMs response to ischemia and reperfusion events using Coverslip Hypoxia

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