Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates αPD-L1 therapy

ABSTRACT: Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates αPD-L1 therapy

PROVIDER: PRJNA935793 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23500205_1.fastq.gz	Fastqsanger.gz
	SRR23500205_2.fastq.gz	Fastqsanger.gz
	SRR23500206_1.fastq.gz	Fastqsanger.gz
	SRR23500206_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates αPD-L1 therapy

Project description:Here, we elucidate a critical microbial-host crosstalk between probiotic-released aryl hydrocarbon receptor (AhR) agonist indole-3-aldehyde (I3A) and CD8 T cells within the tumor microenvironment that potently enhances spontaneous antitumor immunity and facilitates ICI therapy in preclinical melanoma. We used single cell RNA sequencing to phenotype CD8+ T cells within tumors of L. reuteri -treated or untreated mice.

2024-01-01 | GSE225496 | GEO

Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer III

Project description:Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a potential chemopreventive effect. Statins are also associated with reduced dysbiosis in the gut microbiome, yet the role of the gut microbiome in the protective effect of statins in CRC is unclear. Here we validated the chemopreventive role of statins by retrospectively analysing a cohort of patients who underwent colonoscopies. This was confirmed in preclinical models and patient cohorts, and we found that reduced tumour burden was partly due to statin modulation of the gut microbiota. Specifically, the gut commensal Lactobacillus reuteri was increased as a result of increased microbial tryptophan availability in the gut after atorvastatin treatment. Our in vivo studies further revealed that L. reuteri administration suppressed colorectal tumorigenesis via the tryptophan catabolite, indole-3-lactic acid (ILA). ILA exerted anti-tumorigenic effects by downregulating the IL-17 signalling pathway. This microbial metabolite inhibited T helper 17 cell differentiation by targeting the nuclear receptor, RAR-related orphan receptor γt (RORγt). Together, our study provides insights into an anti-cancer mechanism driven by statin use and suggests that interventions with L. reuteri or ILA could complement chemoprevention strategies for CRC.

2023-02-17 | GSE201452 | GEO

Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer II

2023-02-17 | GSE201449 | GEO

Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer I

2023-02-17 | GSE201448 | GEO

Project description:Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates aPD-L1 therapy

| PRJNA925499 | ENA

Dietary tryptophan and circadian rhythms

Project description:Mice were fed a normal chow diet or a tryptophan depleted diet for two weeks under normal 12-hr light/dark cycles (LD) or in constant darkness (DD). Mice were sacrificed every 4th hour over the 24-hr circadian cycle. The suprachiasmatic nucleus (SCN) was harvested and RNA was isolated using a standard TRIZOL protocol. The data suggest that dietary tryptophan is an important component of the diet regulating circadian homeostsis.

2023-05-30 | GSE186242 | GEO

Fecal tryptophan catabolite profiling in newborns in relation to microbiota and antibiotic treatment

Project description:Fecal tryptophan catabolite profiling in newborns in relation to microbiota and antibiotic treatment

| PRJEB79120 | ENA

Dietary tryptophan and circadian rhythms

Project description:Dietary tryptophan and circadian rhythms

| PRJNA773065 | ENA

Dietary tryptophan and circadian rhythms in the Liver

Project description:Mice were fed a normal chow diet or a tryptophan depleted diet for two weeks under normal 12-hr light/dark cycles (LD) or in constant darkness (DD). Mice were sacrificed every 4th hour over the 24-hr circadian cycle. The liver was harvested and RNA was isolated using a standard TRIZOL protocol. The data suggest that dietary tryptophan is an important component of the diet regulating circadian homeostsis.

2023-05-30 | GSE190145 | GEO

Effect of dietary tryptophan deficiency on intestinal ileum gene expression

Project description:To investigate the intestinal ileum response to dietary tryptophan deficiency and the contribution of the intestinal microbiome in regulating these responses

2023-02-21 | GSE222818 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data