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Characterize osteocyte transcriptome under control of PPARa

ABSTRACT: Characterize osteocyte transcriptome under control of PPARa

PROVIDER: PRJNA936585 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23524875_1.fastq.gz	Fastqsanger.gz
	SRR23524875_2.fastq.gz	Fastqsanger.gz
	SRR23524876_1.fastq.gz	Fastqsanger.gz
	SRR23524876_2.fastq.gz	Fastqsanger.gz
	SRR23524877_1.fastq.gz	Fastqsanger.gz

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Characterize osteocyte transcriptome under control of PPARa

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Global hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice fed ad libitum, fasted for 24 hours and re-fed

Project description:If the function of the nuclear receptor PPARa is well-known during a prolongated fasting, its hepatic biological function during feeding and refeeding conditions still needs to be investigated. Moreover, in vivo data collected so far on PPARa function during fasting were obtained using the total Ppara KO transgenic mouse model. To identify genes whose expression is under the strict dependence of hepatic PPARa activity, we generated a new mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to total Ppara KO (KO), wild-type (WT) and liver WT (albumin-Cre-/- Pparaflox/flox or LWT) mice under three nutritional challenges. We used microarrays to detail the global programme of gene expression in liver of Ppara LKO, LWT, Ppara KO and WT male mice fed ad libitum, fasted for 24 hours and refed.

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Whole gene expression data from osteocyte-like cell line MLO-Y4 under large gradient high magnetic field (LG-HMF)

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