Environmentally relevant concentrations of niclosamide disrupt antioxidant defense, histology, and the liver and intestine transcriptome of Chinese soft-shelled turtle
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ABSTRACT:
PROVIDER: PRJNA936854 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR23556621_1.fastq.gz | Fastqsanger.gz | |||
| SRR23556621_2.fastq.gz | Fastqsanger.gz | |||
| SRR23556622_1.fastq.gz | Fastqsanger.gz | |||
| SRR23556622_2.fastq.gz | Fastqsanger.gz | |||
| SRR23556623_1.fastq.gz | Fastqsanger.gz |
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Project description:The gene expression profile in treated CP70 side population spheroid cells (CP70sps cells) was analyzed to investigate the effect of niclosamide inhibition on ovarian tumor-initiating cells. CP70sps cells are isolated and characterized as one kind of ovarian tumor-initiating cells, and they show stemness properties and drug resistance capacity. According gene expression profiles and mechanistic analysis, all evidences revealed niclosamide disrupted multiple metabolic pathways affecting biogenetics, biogenesis and redox regulation. These studies support niclosamide as a promising therapeutic agent for ovarian cancer.
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