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RNA in extracellular vesicles during adolescence reveal immune, energetic and microbial imprints of early life adversity

ABSTRACT: RNA in extracellular vesicles during adolescence reveal immune, energetic and microbial imprints of early life adversity

PROVIDER: PRJNA937742 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23592232_1.fastq.gz	Fastqsanger.gz
	SRR23592232_2.fastq.gz	Fastqsanger.gz
	SRR23592233_1.fastq.gz	Fastqsanger.gz
	SRR23592233_2.fastq.gz	Fastqsanger.gz
	SRR23592234_1.fastq.gz	Fastqsanger.gz

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RNA in extracellular vesicles during adolescence reveal immune, energetic and microbial imprints of early life adversity

Project description:Comparison of bacterial species in gut microbiome and circulating extracellular vesicles

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Effects of early life adversity on male reproductive behavior and the medial preoptic area

Project description:Early life adversity has been linked to altered reproductive development in humans, including changes in the timing of pubertal onset and sexual activity. One common form of early life adversity is having limited access to resources. This form of early life adversity can be modeled in rodents using the limited bedding and nesting model (LBN), in which rat dams and pups are placed in a low resource environment from postnatal day (PND) 2 through 9. Our laboratory has previously shown that male rats raised in LBN conditions have elevated levels of plasma estradiol compared to control males. Female rats, on the other hand, show no effect of LBN on plasma hormone levels, pubertal timing, or estrous cycle duration in adulthood. Here, we find that LBN males also show changes in adult reproductive behaviors. LBN males acquired the suite of reproductive behaviors more quickly than their control counterparts over the course of 3 weeks of testing, showing shorter latencies to mount, intromit, and ejaculate compared to controls prior to the final week of testing. We also characterized LBN-induced gene transcription changes across sex in the medial preoptic area (mPOA) which underlies reproductive behaviors. Interestingly, there was no effect of LBN on puberty onset (as measured by preputial separation) or masculinization of the sexually dimorphic nucleus of the preoptic area (SDN/POA; as measured by calbindin immunoreactivity) in males, suggesting LBN may not exert effects on hormone-dependent measures until after puberty.

2022-02-15 | GSE174753 | GEO

Transcriptional effect of early-life adversity in adult hippocampus

Project description:Transcriptional effect of early-life adversity in adult hippocampus

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Transcriptional effect of early-life adversity in adult hippocampus

Project description:Early-life adversity (ELA) is associated with lifelong memory deficits, yet the responsible mechanisms remain unclear. We imposed ELA by rearing rat pups in simulated poverty, assessed hippocampal memory, and probed changes in gene expression, their transcriptional regulation and the consequent changes in hippocampal neuronal structure. ELA rats had poor hippocampal memory and stunted hippocampal pyramidal neurons, associated with ~140 differentially expressed genes. Upstream regulators of the altered genes included glucocorticoid receptor and, unexpectedly, the transcription factor neuron-restrictive silencer factor (NRSF/REST). NRSF contributed critically to the memory deficits because blocking its function transiently following ELA rescued spatial memory and restored the dendritic arborization of hippocampal pyramidal neurons in ELA rats. Blocking NRSF function in vitro augmented dendritic complexity of developing hippocampal neurons, suggesting that NRSF represses genes involved in neuronal maturation. These findings establish important, surprising contributions of NRSF to ELA-induced transcriptional programming that disrupts hippocampal maturation and memory function.

2020-12-15 | GSE161498 | GEO

Intra-individual methylomics detects the impact of early-life adversity

Project description:Intra-individual methylomics detects the impact of early-life adversity

| PRJNA489840 | ENA

Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation in rhesus monkeys

2016-07-06 | GSE84024 | GEO

Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation in rhesus monkeys

Project description:This study mapped the genome wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through two years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females. Altogether 71 T cell DNA samples were used in 4 different groups (male control, male stress, female control, female stress) at 4 different developmental stage (1 month, before weaning at 6-7 months, after weaning at 9-10 months, and after 2 years at 26-30 months) having 3-6 samples per each group. The DNA samples were pooled in each group and then subjected to Whole Genome Amplification in triplicates.

2016-07-06 | E-GEOD-84024 | biostudies-arrayexpress

Early life adversity promotes sex-specific resilience to opioid addiction-related phenotypes

Project description:Early life adversity promotes sex-specific resilience to opioid addiction-related phenotypes

| PRJNA673395 | ENA

DNA Methylation Differences Associated with Social Anxiety Disorder and Early Life Adversity

Project description:DNA Methylation Differences Associated with Social Anxiety Disorder and Early Life Adversity

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abi4-Energetic Homeostasis and Sugar Signaling

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