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GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development [H9_d7_HiChIP_AP2KO]

ABSTRACT: GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development [H9_d7_HiChIP_AP2KO]

PROVIDER: PRJNA938042 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23597822_1.fastq.gz	Fastqsanger.gz
	SRR23597822_2.fastq.gz	Fastqsanger.gz
	SRR23597823_1.fastq.gz	Fastqsanger.gz
	SRR23597823_2.fastq.gz	Fastqsanger.gz
	SRR23597824_1.fastq.gz	Fastqsanger.gz

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GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development (RNA-Seq)

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GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development (ATAC-Seq)

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GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development (ChIP-Seq)

Project description:GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development (ChIP-Seq)

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GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development (ChIP-Seq)

Project description:ChIP-seq for GRHL2 or AP2a in hESCs treated with RA/BMP4 for 7 days

2023-02-24 | GSE197911 | GEO

GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development (ATAC-Seq)

Project description:ATAC-seq in GRHL2 or AP2a KO hESCs treated with RA/BMP4 for 7 days

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GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development [H9_d7_HiChIP_AP2KO]

Project description:Cohesin HiChIP of AP2a KO hESCs treated with RA/BMP4 for 7 days

2023-02-24 | GSE225922 | GEO

GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development (RNA-Seq)

Project description:RNA-seq in GRHL2 KO hESCs treated with RA/BMP4 for 7 days, or GRHL2 over-expression for 7 days.

2023-02-24 | GSE197913 | GEO

GRHL2 and AP2a coordinate early surface ectoderm lineage commitment and craniofacial development (Multiome)

Project description:scRNA and scATAC in WT and GRHL2 KO hESCs after 7 days of RA/BMP4 (10x multiome)

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GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development.

Project description:Ectodermal dysplasias including skin abnormalities and cleft lip/palate result from improper surface ectoderm (SE) patterning. However, the connection between SE gene regulatory networks and disease remains poorly understood. Here, we dissect human SE differentiation with multiomics and establish GRHL2 as a key mediator of early SE commitment, which acts by skewing cell fate away from the neural lineage. GRHL2 and master SE regulator AP2a balance early cell fate output, with GRHL2 facilitating AP2a binding to SE loci. In turn, AP2a restricts GRHL2 DNA binding away from de novo chromatin contacts. Integration of these regulatory sites with ectodermal dysplasia-associated genomic variants annotated within the Biomedical Data Commons identifies 55 loci previously implicated in craniofacial disorders. These include ABCA4/ARHGAP29 and NOG regulatory regions where disease-linked variants directly affect GRHL2/AP2a binding and gene transcription. These studies elucidate the logic underlying SE commitment and deepen our understanding of human oligogenic disease pathogenesis.

| S-EPMC9950457 | biostudies-literature

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