Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Spatiotemporal understanding of healthy and disordered early pregnancy governed by immune-featured stromal cells

ABSTRACT: Spatiotemporal understanding of healthy and disordered early pregnancy governed by immune-featured stromal cells

PROVIDER: PRJNA940157 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR23681820_1.fastq.gz	Fastqsanger.gz
	SRR23681820_2.fastq.gz	Fastqsanger.gz
	SRR23681821_1.fastq.gz	Fastqsanger.gz
	SRR23681821_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 37

Similar Datasets

Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [RNA-seq]

Project description:Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [RNA-seq]

| PRJNA940159 | ENA

Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [Spatial Transcriptomics]

Project description:Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [Spatial Transcriptomics]

| PRJNA1054179 | ENA

Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [scRNA-seq]

Project description:Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [scRNA-seq]

| PRJNA940162 | ENA

Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [Spatial Transcriptomics]

Project description:Endometrial decidualization connecting embryo implantation and placentation is transient but essential for successful pregnancy, which, however, is not systematically investigated. Here, we use a scStereo-seq technology to spatially visualize and deﬁne the dynamic functional decidual hubs assembled by distinct immune, endothelial, trophoblast, and decidual stromal cells (DSCs) in early pregnant mice. We unravel the DSC transdifferentiation trajectory and surprisingly discover a dual-featured type of immune-featured DSCs (iDSCs). We ﬁnd that immature DSCs attract immune cells and induce decidual angiogenesis at the mesenchymalepithelial transition hub during decidualization initiation. iDSCs enable immune cell recruitment and suppression, govern vascularization, and promote cytolysis at immune cell assembling and vascular hubs, respectively, to establish decidual homeostasis at a later stage. Interestingly, dysfunctional and spatially disordered iDSCs cause abnormal accumulation of immune cells in the vascular hub, which disrupts decidual hub speciﬁcation and eventually leads to pregnancy complications in DBA/2-mated CBA/J mice.

2023-12-18 | GSE250503 | GEO

Spatiotemporal understanding of healthy and disordered early pregnancy governed by immune-featured stromal cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-12 | GSE226430 | GEO

Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [RNA-seq]

Project description:Endometrial decidualization connecting embryo implantation and placentation is transient, but essential for successful pregnancy, which however is not systematically investigated. Here, by using a novel single-cell spatial transcriptomic profiling technology (scStereo-seq), we were able to visualize and define key and dynamic functional decidual hubs assembled by distinct immune, endothelial, trophoblast and decidual stromal cells (DSCs) during early pregnancy in mice. We classified DSC subclusters and described their transdifferentiation trajectory controlled by transcription factor cascades. Interestingly, we discovered a novel type of DSCs expressing immune cell-specific genes, termed immune DSCs (iDSCs). Whereas immature DSCs attracted immune cells and induced decidual angiogenesis at the mesenchymal-to-epithelial transition (MET) hub during decidualization initiation, iDSCs enabled immune cell recruitment, angiogenesis facilitation and cytotoxic effect induction to form immune cell assembling and angiogenesis hubs, which eventually allow decidual homeostasis maintenance and decidualization-to-placentation transition. We spatiotemporally decode mouse early pregnancy events controlled by immune DSCs.

2023-09-12 | GSE226429 | GEO

Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells [scRNA-seq]

2023-09-12 | GSE226417 | GEO

High-definition spatiotemporal atlas of cholestatic injury and repair.

Project description:Cholestatic injuries, featured with regional damage around the periportal, cause considerable mortality without curative therapies. It is technically challenging to dissect regional cell-cell interactions and molecular changes to fully understand cholangiopathies. Here, we generated a high-definition atlas of spatiotemporal transcriptome during cholestatic injury and repair. Remarkably, cholangiocytes functioned as a periportal hub by integrating signals from neighboring cells. We also dissected periportal damage, spatial heterogenous reprogramming and zonal regeneration, which appeared to be strongly associated with cholangiocyte. Moreover, spatiotemporal analyses revealed a key inhibitory rheostat for hepatocyte proliferation. Together, our study provides a comprehensive resource that is instrumental to demarcate regional cholestatic injury.

2022-12-02 | GSE219169 | GEO

Spatiotemporal multi-omics decoding of the developing human spinal cord II

Project description:The human spinal cord contains diverse cell types, governed by a series of spatiotemporal events for tissue assembly and functions. However, the regulation of cell fate specification in the human developing spinal cord remains largely unknown. By performing single-cell and spatial multi-omics methods, we integrated the datasets and created a comprehensive human developmental atlas of the first trimester spinal cord. Unexpectedly, we discovered unique events in human spinal cord development, including early loss of active neural stem cells, simultaneous occurrence of neurogenesis and gliogenesis, and distinct spatiotemporal genetic regulations of fate choices. We also identified distinct regulations of cancer stem cells in ependymomas from our atlas. Thus, we demonstrate spatiotemporal genetic regulation of human spinal cord development and its potential to understand novel disease mechanisms.

2023-04-25 | GSE219121 | GEO

Spatiotemporal multi-omics decoding of the developing human spinal cord I

2023-04-25 | GSE219120 | GEO