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MiR-483 to 8OH-G miR-483 transversion changes mRNA targetomes in Ecs

ABSTRACT: miR-483 to 8OH-G miR-483 transversion changes mRNA targetomes in Ecs

PROVIDER: PRJNA941193 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23704312_1.fastq.gz	Fastqsanger.gz
	SRR23704312_2.fastq.gz	Fastqsanger.gz
	SRR23704313_1.fastq.gz	Fastqsanger.gz
	SRR23704313_2.fastq.gz	Fastqsanger.gz
	SRR23704314_1.fastq.gz	Fastqsanger.gz

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miR-483 to 8OH-G miR-483 transversion changes mRNA targetomes in Ecs

Project description:To explore the transcriptional changes in endothelial cells (ECs) caused by the 8OH-G miR-483 transversion, we overexpressed miR-483 or 8OH-G miR-483 in ECs and profiled transcriptomes by RNA-seq We then performed gene expression profiling analysis using data obtained from RNA-seq.

2023-03-07 | GSE226665 | GEO

Overexpression of miR-483-3p in human keratinocytes

Project description:HaCaT human keratinocytes were transfected with pre-miR-483-3p or pre-miR-NC. RNA samples were harvested 48h post-transfection and mRNA profiles were determined with pan genomic arrays. Two biological replicates were performed for each comparison. Data were normalized using a dye-swap method.

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Transcriptome data of miR-483 overexpression in human pulmonary arterial endothelial cells

Project description:MicroRNA-483 (miR-483) regulate endothelial function through inhibition expression of connective tissue growth factor (CTGF). Endothelial dysfunction is involved in the pathogeneis of pulmonary arterial hypertension (PAH). We investigated the role of miR-483 overexpression on human pulmonary arterial endothelial cells (hPAECs) through comparing the transcriptome file of hPAECs transfected with miR-483 -3p and -5p mimic and with control mimic. Gene ontology analysis showed that several PAH-associated signaling pathways were regulated by miR-483, including transforming growth factor-β signaling, Wnt signaling and inflammatory response, cell adhesion, response to hypoxia, apoptotic processes, oxidative reduction processes and negative regulation of cell migration and proliferation.

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miR-483 overexpression in human sarcoma cell line MHH-ES-1.

Project description:miRNA abnormalities are increasingly relevent to cancer development, We used microarrays to detail the global programme of gene expression upon miR-483 overexpression in sarcoma cell line MHH-ES-1. MHH-ES-1 cells were transfected with miR-483-5p, -3p or scrambled control mimics and then harvested 48 hours after to isolate total RNAs using Trizol reagent (Invitrogen). Total RNA was converted to cRNA probes using the BioArray High Yield Transcript Labeling Kit (ENZO diagnostics), and hybridized to Affymetrix GeneChip human HG-U133ver2+ 3’-mRNA expression microarray chips using protocol EukGEs2v4 on the GeneChip Fluidic Station.

2013-12-31 | E-GEOD-50980 | biostudies-arrayexpress

Identification of genes suppressed by miR-483-5p and miR-551a in a colon cancer cell-line

Project description:miR-483-5p and miR-551a were over-expressed in a colon cancer cell-line LvM3b to identify genes that are down-regulated by the miRNAs over-expression. Total RNA was isolated from miR-483-5p or miR-551a over-expressing LvM3b cells as well as control LvM3b cells.

2015-01-16 | E-GEOD-63041 | biostudies-arrayexpress

Identification of genes suppressed by miR-483-5p and miR-551a in a colon cancer cell-line (study 2)

2015-01-16 | E-GEOD-63201 | biostudies-arrayexpress

Identification of genes suppressed by miR-483-5p and miR-551a in a colon cancer cell-line

Project description:miR-483-5p and miR-551a were over-expressed in a colon cancer cell-line LvM3b to identify genes that are down-regulated by the miRNAs over-expression.

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RNA-sequencing analysis gene expression changes in response to ischemia reperfusion and upon manipulation of miR-483-5p in PC12 highly differentiated cells

Project description:The consequences of cardiac arrest are often fatal, including brain injury after resuscitation. It has been reported that few people patients can recover to the neurological state before cardiac arrest. MiRNAs are short non-protein-coding RNA molecules that are evolutionarily conserved and ubiquitously expressed. Numerous pieces of research have reviewed the role of miRNAs in regulating neuronal apoptosis, regeneration, and plasticity of neurons, and inflammatory after cardiac arrest . As the stability of miRNAs in the bloodstream and the function in the regulation of neurological impairment after ischemia-reperfusion injury, microRNAs have been the most potential new biomarkers and therapeutic targets after cardiac arrest to alleviate neurological impairment . In this work, we found that the level of miR-483-5p is correlated to the prognosis of neurological function. To investigate the function of miR-483-5p on neurons after ischemia-reperfusion injury,we established highly differentiated PC12 cell lines in which miR-483-5p was overexpressed by transfection with miR-483-5p mimcis.We then performed gene expression profiling analysis using data obtained from RNA-seq of PC12 cells in different groups.

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miR-483 overexpression in human sarcoma cell line MHH-ES-1.

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