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Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice

ABSTRACT: Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice

PROVIDER: PRJNA941202 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23704962.fastq.gz	Fastqsanger.gz
	SRR23704963.fastq.gz	Fastqsanger.gz
	SRR23704964.fastq.gz	Fastqsanger.gz
	SRR23704965.fastq.gz	Fastqsanger.gz
	SRR23704966.fastq.gz	Fastqsanger.gz

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Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice

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Project description:In the present study, RNA-seq were performed To identify clinical relevance of PLAUR, a putative Serpin E1 receptor, in cutaneous itch signaling and crosstalk pathways with other critical itch modulators.mRNA profiles were generated by deep sequencing, in triplicate, using MGISEQ-2000. Our experiment showed Serpin E1-treatment further led to a marked upregulation of TLR2 transcript in mDRG neurons, along with enhanced transcription of cosignaling proteins belonging to pro-inflammatory signaling pathways including NF-κB signaling proteins. We next investigated the consequence of TLR2 activation in mTGNs using the TLR agonists, Pam3CSK4 (TLR1/2 agonist), FSL-1 (TLR2/6 agonist), or vehicle. Among these transcripts, TLR2 was found upregulated strongest by both TLR2 agonists suggesting a selfenhancing feedback loop of TLR2 activation.The PLAUR-TLR2 axis promotes cutaneous inflammation and itch, both feeding into an aggravation of AD. This finding might help us to better understand the skin-nerve communication in itch circuits.

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