Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential transcriptome responses in human THP-1 macrophages following exposure to T98G and LN-18 human glioblastoma secretions: a simplified bioinformatics approach to understanding patient-glioma-specific effects on tumor-associated macrophages

ABSTRACT: Differential transcriptome responses in human THP-1 macrophages following exposure to T98G and LN-18 human glioblastoma secretions: a simplified bioinformatics approach to understanding patient-glioma-specific effects on tumor-associated macrophages

PROVIDER: PRJNA941337 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23716525_1.fastq.gz	Fastqsanger.gz
	SRR23716525_2.fastq.gz	Fastqsanger.gz
	SRR23716526_1.fastq.gz	Fastqsanger.gz
	SRR23716526_2.fastq.gz	Fastqsanger.gz
	SRR23716527_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Differential transcriptome responses in human THP-1 macrophages following exposure to T98G and LN-18 human glioblastoma secretions: a simplified bioinformatics approach to understanding patient-glioma-specific effects on tumor-associated macrophages

Project description:We first describe a methods approach to differentiating THP-1 monocytes to macrophages with M0-like genotype. Then we describe the effect that different glioblastoma supernatants have on the gene expression profiles of macrophages, suggesting gliomas should be considered different diseases.

2023-03-13 | GSE226757 | GEO

T98G growth arrest

Project description:Triplicate experiments from T98G cells under asynchronously growing, and growth arrest by serum deprivation and contact inhibition. Keywords: other

2004-11-05 | GSE1692 | GEO

Heterogeneity of LN resident macrophage

Project description:LN resident macrophages lining the lymphatic sinuses play critical roles in antigen capture and presentation as well as degradation. We used microarray to examine global gene expression profiles to compare SCS and med macrophages to determine the underlying molecular basis of their differential handling of antigens. Primary SCS and med macrophages were isolated and purified from LNs by flourescence-activated cell sorting and RNA extracted, amplified and hybridized for Affymetrix analysis.

2009-06-05 | E-GEOD-15767 | biostudies-arrayexpress

Heterogeneity of LN resident macrophage

2009-06-05 | GSE15767 | GEO

Simplified ChIP-exo assays

Project description:Simplified ChIP-exo assays

| PRJNA434276 | ENA

LN immunoinfiltrate analysis

Project description:LN immunoinfiltrate analysis

| PRJNA634254 | ENA

Simplified ChIP-exo assays II

Project description:Simplified ChIP-exo assays II

| PRJNA471904 | ENA

Overall gene expression was evaluated in lnc CHASERR transfected human glioma T98G cells. The transcriptome of T98G cells transfected with sh-NC and sh-lnc CHASERR were compared.

Project description:We used high-throughput sequencing to analyse differentially expressed genes among human glioma cells T98G transfected with sh-lnc CHASERR.

2023-12-07 | GSE249202 | GEO

Gene expression profiling of WWOX-overexpressing glioblastoma T98G cells

Project description:The WWOX gene is known for its tumor suppressor character and seems to be one of the main cellular regulators of cell cycle and apoptosis. The aim of the study was to identify cellular pathways and biological processes influenced by WWOX in glioblastoma cells. Our experiment showed that in this type of cancer WWOX, beside cell cycle and apoptosis control, may be involved in metabolism, cytoskeleton structure and differentiation. T98G glioblastoma cells were stably transfected with WWOX cDNA. T98G cells transfected with an empty vector served as a control. Total mRNA was isolated to look for gene-expression differences induced by the WWOX overexpression.

2013-10-22 | E-GEOD-51481 | biostudies-arrayexpress

RNAseq of oncogene-induced senescent murine macrophages

Project description:Aging organisms accumulate senescent cells, which are the result of exposure to important stress such as telomere attrition, irradiation, oncogene activation, oxidative stress or cytotoxic drugs. These senescent cells are characterized by a stable cell cycle arrest and an important secretion of pro-inflammatory factors. This senescence-associated secretory phenotype (SASP) has been shown to promote chronic inflammation leading to age-associated diseases. While a lot of in vitro models of senescence focus on senescent fibroblasts, it has been shown that a major portion of the burden of senescent cells in old mice are macrophages. Senescent macrophages have been shown to contribute to atherosclerosis, neurodegenerative diseases and macular degeneration. Yet little is known about senescent macrophages. Considering their potential role in age-associated diseases, we think these senescent macrophages and their secretions need to be investigated. Here we aimed to establish and characterize an in vitro model for oncogene-induced senescence in macrophages, to characterize secretions of these senescent macrophages and to assess impacts of these secretions on recipient cells.

2021-06-29 | GSE153508 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data