Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Whole-Transcriptome RNA expression profiling for human normal arterial intimae and advanced atherosclerotic plaques

ABSTRACT: Whole-Transcriptome RNA expression profiling for human normal arterial intimae and advanced atherosclerotic plaques

PROVIDER: PRJNA941797 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23722634_1.fastq.gz	Fastqsanger.gz
	SRR23722634_2.fastq.gz	Fastqsanger.gz
	SRR23722635_1.fastq.gz	Fastqsanger.gz
	SRR23722635_2.fastq.gz	Fastqsanger.gz
	SRR23722636_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

miRNA expression profiling for human normal arterial intimae and advanced atherosclerotic plaques

Project description:miRNA expression profiling for human normal arterial intimae and advanced atherosclerotic plaques

| PRJNA941796 | ENA

Whole-Transcriptome RNA expression profiling for human normal arterial intimae and advanced atherosclerotic plaques

Project description:To analyze the cause of arterial plaque formation and development, our arteries in patients with normal donors and severe arterial plaques sampling, the transcriptome sequencing, to explore its molecular mechanism.

2023-05-25 | GSE226790 | GEO

miRNA expression profiling for human normal arterial intimae and advanced atherosclerotic plaques

2023-05-25 | GSE226791 | GEO

profiles of microRNA expression of atherosclerotic plaques

Project description:To investigate the expression profiles of miRNA in atherosclerotic plaques, the global features of miRNAs expression of three normal coronary artery tissues sample pools and three sample pools of advanced atherosclerosis plaques of coronary artery were studied using microarray technology,

2015-02-20 | E-MTAB-2460 | biostudies-arrayexpress

Gene Expression in early and advanced atherosclerotic plaque from human carotid

Project description:The objective of this study is to identify genes and pathways involved in the progression of atherosclerotic plaques from early to advanced stage in humans.

2011-04-25 | GSE28829 | GEO

Gene Expression in early and advanced atherosclerotic plaque from human carotid

Project description:The objective of this study is to identify genes and pathways involved in the progression of atherosclerotic plaques from early to advanced stage in humans. Samples from atherosclerotic carotid artery segments, from early ((pathological) intimal thickening and intimal xanthoma) and from advanced (thin or thick fibrous cap atheroma) lesions, have been retrieved from the Maastricht Pathology Tissue Collection (MPTC). Tissue was obtained during autopsy (Dept of Pathology, Maastricht University Medical Centre). Collection, storage in the Maastricht Pathology Tissue Collection (MPTC) and use of tissue and patient data were performed in agreement with the "Code for Proper Secondary Use of Human Tissue"

2011-04-25 | E-GEOD-28829 | biostudies-arrayexpress

LncRNA/mRNA expression profiling for human normal arterial intimae and advanced atherosclerotic plaques

Project description:In microarray analysis, we have characterized the lncRNA and mRNA profiles in three advanced atherosclerosis samples and in three normal intima tissues. A total of 30,586 lncRNAs and 26,109 coding transcripts were detected by microarray analysis. The microarray profiling analysis not only provides new insights into the pathogenesis of atherosclerosis, but may also reveal new biomarkers for its diagnosis and treatment.

2019-03-18 | GSE97210 | GEO

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

Project description:Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages and human atherosclerotic plaques. We demonstrate that myeloid Acly deficiency induces a stable plaque phenotype characterized by increased collagen deposition and fibrous cap thickness, along with a smaller necrotic core. In-depth functional, lipidomic, and transcriptional characterization indicate deregulated fatty acid and cholesterol biosynthesis and reduced liver X receptor (LXR) activation within the macrophages in vitro. This results in macrophages that are more prone to undergo apoptosis, whilst presenting increased phagocytosis of apoptotic cells. Together, our results indicate that targeting macrophage metabolism improves atherosclerosis outcome and we reveal Acly as a promising therapeutic target to stabilize atherosclerotic plaques.

2020-02-18 | GSE126690 | GEO

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

Project description:Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages and human atherosclerotic plaques. We demonstrate that myeloid Acly deficiency induces a stable plaque phenotype characterized by increased collagen deposition and fibrous cap thickness, along with a smaller necrotic core. In-depth functional, lipidomic, and transcriptional characterization indicate deregulated fatty acid and cholesterol biosynthesis and reduced liver X receptor activation within the macrophages in vitro. This results in macrophages that are more prone to undergo apoptosis, whilst maintaining their capacity to phagocytose apoptotic cells. Together, our results indicate that targeting macrophage metabolism improves atherosclerosis outcome and we reveal Acly as a promising therapeutic target to stabilize atherosclerotic plaques.

2021-03-05 | MTBLS2159 | MetaboLights

Transcription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient

Project description:We compared gene expression profiles between asymptomatic and symptomatic atherosclerotic plaques from the same patient. This was accomplished by analyzing carotid plaques from four patients with bilateral high-grade carotid artery stenoses one being symptomatic (TIA or stroke) and the other asymptomatic.

2006-02-10 | E-MEXP-268 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data