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Expression data from mothers, placentas, and newborns in the Democratic Republic of Congo

ABSTRACT: Expression data from mothers, placentas, and newborns in the Democratic Republic of Congo

PROVIDER: PRJNA942634 | ENA |

REPOSITORIES: ENA

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Expression data from mothers, placentas, and newborns in the Democratic Republic of Congo

Project description:Maternal stress has long been associated with lower birthweight but mechanisms remain elusive. This study explored how maternal stress may impact changes in gene expression within a cohort of mother-placenta-newborn triads in the eastern Democratic Republic of Congo We used microarrays to detail the global programme of gene expression underlying the impact of maternal stress on newborn birthweight and identified that global placental gene expression may partially mediate the negative impact of maternal war stress on newborn birthweight.

2023-03-10 | GSE226993 | GEO

Epigenetic analysis of psychosocial stress among mother-newborn dyads in the Democratic Republic of Congo (EAA)

Project description:Prenatal maternal stress has a negative impact on child health but the mechanisms through which maternal stress affects child health are unclear. Epigenetic variation, such as DNA methylation, is a likely mechanistic candidate as DNA methylation is sensitive to environmental insults and can regulate long-term changes in gene expression. We recruited mother-newborn dyads in the Democratic Republic of Congo to investigate the effects of maternal stress on DNA methylation in mothers and newborns. We used four measures of maternal stress to capture a range of stressful experiences: general trauma, sexual trauma, war trauma, and chronic stress. We identified differentially methylated positions (DMPs) associated with general trauma, sexual trauma, and war trauma in both mothers and newborns. No DMPs were associated with chronic stress. Sexual trauma was positively associated with epigenetic age acceleration across several epigenetic clocks in mothers. General trauma and war trauma were positively associated with newborn epigenetic age acceleration using the extrinsic epigenetic age clock. We tested the top DMPs for enrichment of DNase I hypersensitive sites (DHS) and found no enrichment in mothers. In newborns, top DMPs associated with war trauma were enriched for DHS in embryonic and fetal cell types. Finally, one of the top DMPs associated with war trauma in newborns also predicted birthweight, completing the cycle from maternal stress to DNA methylation to newborn health outcome. Our results indicate that maternal stress is associated with site-specific changes in DNAm and epigenetic age acceleration in both mothers and newborns.

2023-06-08 | GSE224363 | GEO

Epigenetic analysis of psychosocial stress among mother-newborn dyads in the Democratic Republic of Congo (EWA reanalysis)

2023-06-08 | GSE224364 | GEO

Longitudinal analysis of birthweight and epigenetic aging among children from birth to age three in the Democratic Republic of Congo

Project description:Genome-wide DNA methylation profiling of venous blood samples from children in the Eastern Democratic Republic of Congo from birth to age three. DNA methylation data were noob normalized and uploaded to Steve Horvath's epigenetic age calculator website to calculate Horvath epigenetic age acceleration for each participant at each timepoint for which they had data available. Replicates were averaged and a single outlier at birth was removed as described in the manuscript, leaving 155 observations from 67 unique individuals. Sample size at each timepoint was as follows: n = 64 at birth, n = 8 at six months, n= 35 at one year, n = 32 at two years, and n = 16 at three years.

2023-06-26 | GSE224573 | GEO

WGS of S. aureus from the Democratic Republic of Congo

Project description:Whole genome sequencing of S. aureus from the Democratic Republic of Congo

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multidrug-resistant Escherichia coli in the Democratic Republic of Congo

Project description:Whole-genome sequences of multidrug-resistant Escherichia coli in South-Kivu Province, Democratic Republic of Congo: characterization of phylogenomic changes, virulence and resistance genes

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Epigenetic analysis of psychosocial stress among mother-newborn dyads in the Democratic Republic of Congo

Project description:Epigenetic analysis of psychosocial stress among mother-newborn dyads in the Democratic Republic of Congo

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Epigenetic analysis of psychosocial stress among mother-newborn dyads in the Democratic Republic of Congo (EAA)

Project description:Epigenetic analysis of psychosocial stress among mother-newborn dyads in the Democratic Republic of Congo (EAA)

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Genomic study of seventh pandemic Vibrio cholerae El Tor isolates from the Democratic Republic of Congo

Project description:Genomic study of seventh pandemic Vibrio cholerae El Tor isolates from the Democratic Republic of Congo

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Prenatal Maternal Stress Predicts Methylation of Genes Regulating the Hypothalamic-Pituitary-Adrenocortical System in Mothers and Newborns in the Democratic Republic of Congo.

Project description:Exposure to stress early in life permanently shapes activity of the hypothalamic-pituitary-adrenocortical (HPA) axis and the brain. Prenatally, glucocorticoids pass through the placenta to the fetus with postnatal impacts on brain development, birth weight (BW), and HPA axis functioning. Little is known about the biological mechanisms by which prenatal stress affects postnatal functioning. This study addresses this gap by examining the effect of chronic stress and traumatic war-related stress on epigenetic changes in four key genes regulating the HPA axis in neonatal cord blood, placenta, and maternal blood: CRH, CRHBP, NR3C1, and FKBP5. Participants were 24 mother-newborn dyads in the conflict-ridden region of the eastern Democratic Republic of Congo. BW data were collected at delivery and maternal interviews were conducted to assess culturally relevant chronic and war-related stressors. Chronic stress and war trauma had widespread effects on HPA axis gene methylation, with significant effects observed at transcription factor binding (TFB) sites in all target genes tested. Some changes in methylation were unique to chronic or war stress, whereas others were observed across both stressor types. Moreover, stress exposures impacted maternal and fetal tissues differently, supporting theoretical models that stress impacts vary according to life phase. Methylation in several NR3C1 and CRH CpG sites, all located at TFB sites, was associated with BW. These findings suggest that prenatal stress exposure impacts development via epigenetic changes in HPA axis genes.

| S-EPMC4733886 | biostudies-literature

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