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MiRNA expression in male mice in the basolateral amygdala following restraint stress

ABSTRACT: miRNA expression in male mice in the basolateral amygdala following restraint stress

PROVIDER: PRJNA942924 | ENA |

REPOSITORIES: ENA

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miRNA expression in male mice in the basolateral amygdala following restraint stress

Project description:Analysis of miRNA expression in amygdalae of male C57BL/6J mice following a 6-hour of restraint stress in comparison to control, stress-naïve animals. In this study, we identified overxepression of miR-483-5p in the amygdala of male mice following stress.

2023-03-27 | GSE227028 | GEO

Discrete and continuous heterogeneity in the basolateral amygdala

Project description:Basolateral excitatory neurons constitute a prominent output neuron class of the amygdala. Here, we examined diversity in this cell type using single-cell RNA-seq.

2020-08-28 | GSE148866 | GEO

THE EFFECTS OF ALCOHOLISM ON THE HUMAN BASOLATERAL AMYGDALA

Project description:Alcohol affects gene expression in several brain regions. The amygdala is a key structure in the brainâs emotional system and in recent years the crucial importance of the amygdala in drug-seeking and relapse has been increasingly recognized. In this study gene expression screening was used to identify genes involved in alcoholism in the human basolateral amygdala. The results show that alcoholism affects a broad range of genes and many systems including genes involved in synaptic transmission, neurotransmitter transport, structural plasticity, metabolism, energy production, transcription and RNA processing and the circadian cycle. In particular, genes involved in the glutamate system were affected in the alcoholic patients. In the amygdala the glutamate system is involved in the acquisition, consolidation, expression and extinction of associative learning, which is a vital part of addiction, and in alcohol abusers it is associated with withdrawal anxiety and neurodegeneration. Downregulation of the excitatory amino acid transporters GLAST, GLT-1 and the AMPA glutamate receptor 2 (GluR2) revealed by the microarray were confirmed by Western blots. The decreased expression of GLAST, GLT-1 and GluR2 in the alcoholic patients may increase glutamate tone and activity in the basolateral amygdala and this may contribute to neurodegeneration as well as the expression of associative memories and anxiety which underlie continued drug-seeking and chronic relapse. Two-condition experiment, alcoholics vs controls. Biological replicates: 6 alcoholics 6 controls, one replicate per array.

2010-05-22 | E-GEOD-18212 | biostudies-arrayexpress

Effect of Isoflurane and LTM on basolateral amygdala

Project description:Fear conditioning in rats leads to long term memory (LTM) formation. A central neural substrate for LTM is the basolateral amygdala. We sought the expression changes specific to LTM at 6h following anesthesia with isoflurane (a general anesthetic and an effective amnestic agent), following pain (a component of conditioning), and following conditioning in presence and absence of isoflurane. Keywords = anesthesia, amygdala, LTM, Rampil, Isoflurane, fear, memory Keywords: other

2004-12-31 | GSE1779 | GEO

THE EFFECTS OF ALCOHOLISM ON THE HUMAN BASOLATERAL AMYGDALA

Project description:Alcohol affects gene expression in several brain regions. The amygdala is a key structure in the brain’s emotional system and in recent years the crucial importance of the amygdala in drug-seeking and relapse has been increasingly recognized. In this study gene expression screening was used to identify genes involved in alcoholism in the human basolateral amygdala. The results show that alcoholism affects a broad range of genes and many systems including genes involved in synaptic transmission, neurotransmitter transport, structural plasticity, metabolism, energy production, transcription and RNA processing and the circadian cycle. In particular, genes involved in the glutamate system were affected in the alcoholic patients. In the amygdala the glutamate system is involved in the acquisition, consolidation, expression and extinction of associative learning, which is a vital part of addiction, and in alcohol abusers it is associated with withdrawal anxiety and neurodegeneration. Downregulation of the excitatory amino acid transporters GLAST, GLT-1 and the AMPA glutamate receptor 2 (GluR2) revealed by the microarray were confirmed by Western blots. The decreased expression of GLAST, GLT-1 and GluR2 in the alcoholic patients may increase glutamate tone and activity in the basolateral amygdala and this may contribute to neurodegeneration as well as the expression of associative memories and anxiety which underlie continued drug-seeking and chronic relapse.

2009-09-24 | GSE18212 | GEO

Activity-dependent transcriptional profiling of basolateral amygdala neurons in response to valence-specific stimuli

Project description:Activity-dependent transcriptional profiling was performed in the basolateral amygdala in order to identify unique genetic markers for functionally distinct neuronal populations

2016-10-16 | GSE78137 | GEO

Transcriptomic profiling of KLB expressing cells in the basolateral amygdala

Project description:KLB-Cre mice were crossed to Ai14 mice to label KLB-expressing cells with tdTomato. The basolateral amygdala was then dissected out and tdTomato positive cells were isolated using FACs sorting. FACs sorted cells were then captured for single cell RNA sequencing analysis using the BD Rhapsody Whole Transcriptome Analysis kit.

2022-02-01 | GSE192367 | GEO

hCyfip1 overexpression in the basolateral amygdala of mice

Project description:hCyfip1 overexpression in the basolateral amygdala of mice

| PRJNA517186 | ENA

Discrete and continuous heterogeneity in the basolateral amygdala

Project description:Discrete and continuous heterogeneity in the basolateral amygdala

| PRJNA625988 | ENA

Developmentally regulated sex differences in K48 polyubiquitination in the amygdala

Project description:This project examined if sex differences in K48 polyubiquitination in the amygdala were developmentally regulated. This used basolateral amygdala (BLA) samples collected from 4 and 9 week old male and female Sprague-Dawley rats.

2023-11-06 | PXD042021 | Pride

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