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The effect of a BCCA-free, with 1% propionate, diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC with propionate-ChIP-Seq]

ABSTRACT: The effect of a BCCA-free, with 1% propionate, diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC with propionate-ChIP-Seq]

PROVIDER: PRJNA944182 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23848236.fastq.gz	Fastqsanger.gz
	SRR23848237.fastq.gz	Fastqsanger.gz
	SRR23848238.fastq.gz	Fastqsanger.gz
	SRR23848239.fastq.gz	Fastqsanger.gz
	SRR23848240.fastq.gz	Fastqsanger.gz

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Similar Datasets

The effect of a BCCA-free, with 1% propionate, diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC with propionate-ChIP-Seq]

Project description:Identifying branched-chain amino acid (BCAA) oxidation enzymes in the nucleus led us to predict that they are a source of propionyl-CoA that could be utilized for histone propionylation and, thereby, regulate gene expression. To investigate this and its effect on the development of cardiac hypertrophy and failure, we applied pressure overload on the heart in mice maintained on a diet with standard levels of BCAA (BCAA-control) versus a BCAA-free diet. The former was associated with an increase in H3K23-propionyl (H3K23Pr) at the promoters of upregulated genes [e.g., cell signaling and extracellular matrix (ECM) genes] and a decrease at the promoters of downregulated genes [e.g., electron transfer complex (ETC I-V) and metabolic genes]. Intriguingly, the BCAA-free diet diminished the increase in promoter-H3K23Pr and significantly reduced ECM gene expression and collagen deposition. Conversely, the BCAA-free diet abolished the downregulation of ETC I-V subunits, enhanced mitochondrial respiration, and curbed cardiac hypertrophy. Thus, lowering the intake of BCAA reduces histone propionylation, which moderates the effects of stress on the heart.

2023-08-25 | GSE227226 | GEO

The effect of a BCCA-free diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC-ChIP-Seq]

Project description:The effect of a BCCA-free diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC-ChIP-Seq]

| PRJNA944183 | ENA

The effect of a BCCA-free diet on 1W pressure overload-induced H3K23-propionyl [BCAA-free-1W-TAC-ChIP-Seq]

2023-08-25 | GSE227227 | GEO

The effect of a BCCA-free diet, with 1% propionate, on 1W pressure overload-induced cardiac gene expression [BCAA-free w propionate-1W-TAC-RNA-Seq]

Project description:The effect of a BCCA-free diet, with 1% propionate, on 1W pressure overload-induced cardiac gene expression [BCAA-free w propionate-1W-TAC-RNA-Seq]

| PRJNA944181 | ENA

The effect of a BCCA-free diet, with 1% propionate, on 1W pressure overload-induced cardiac gene expression [BCAA-free w propionate-1W-TAC-RNA-Seq]

2023-08-25 | GSE227225 | GEO

The effect of a BCCA-free diet on 1W pressure overload-induced cardiac gene expression

2023-08-25 | GSE227110 | GEO

The effect of a BCCA-free diet on 2W pressure overload-induced H3K23-propionyl [BCAA-free-2W-TAC-ChIP-Seq]

2023-08-25 | GSE227228 | GEO

The effect of a BCCA-free diet on 1W pressure overload-induced cardiac gene expression

Project description:The effect of a BCCA-free diet on 1W pressure overload-induced cardiac gene expression

| PRJNA943243 | ENA

The effect of a BCCA-free diet on 2W pressure overload-induced H3K23-propionyl [BCAA-free-2W-TAC-ChIP-Seq]

Project description:The effect of a BCCA-free diet on 2W pressure overload-induced H3K23-propionyl [BCAA-free-2W-TAC-ChIP-Seq]

| PRJNA944184 | ENA

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation [ChIP-Seq 2]

Project description:Propiogenic substrate catabolism and gut bacteria produce propionate, a post-translational protein modifier. Here, using a mouse model of propionic acidaemia (PA), we characterise how disturbances to propionate metabolism modify histones and affect cardiac gene expression and function. Plasma propionate was raised in PA mice, but male hearts accumulated a smaller propionyl-CoA excess, correlating with -alanine build-up. Raising -alanine experimentally in myocytes cultured under propionate-stress reduced propionyl-CoA and partially reversed the propionate-evoked metabolic disturbance. Female PA hearts manifested a moderate diastolic dysfunction phenotype, with raised diastolic [Ca2+], expanded end-systolic ventricular volume, and reduced stroke volume. Differentially-expressed genes included Pde9a and Mme that relate to contractile dysfunction through down-scaled cGMP signalling, consistent with phosphoproteome changes. Propionate was traced to histone H3 propionylation and increased acetylation genome-wide, including at Pde9a and Mme promoters, with more pronounced effects in female PA hearts. We link perturbed propionate metabolism to epigenetic changes that impact cardiac function.

2023-09-28 | GSE205837 | GEO

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