Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lactational exposure to high fat diet

ABSTRACT: Lactational exposure to high fat diet

PROVIDER: PRJNA944671 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23862877.fastq.gz	Fastqsanger.gz
	SRR23862878.fastq.gz	Fastqsanger.gz
	SRR23862879.fastq.gz	Fastqsanger.gz
	SRR23862880.fastq.gz	Fastqsanger.gz
	SRR23862881.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 11

Similar Datasets

Effect of lactational high fat diet on offspring liver RNA expression

Project description:The goal was to study the long term metabolic programming effects of exposure of offspring to a dam eating 60% high fat diet during the lactation period only. We previously showed that offspring from dams given lactational high fat diet (HFD) are predisposed to obesity, glucose intolerance and inflammation. The purpose of these studies was to understand the programming implications of lactational HFD on offspring metabolic liver disease risk. Dams were fed a 60% lard-based HFD from the day of delivery through the 21 day lactation period. Starting at weaning offspring were fed normal fat diet until 3 months of age at which point a subset were challenged with an additional HFD stressor. Lactational HFD fed male offspring developed hepatic insulin resistance. Postweaning HFD challenge led male offspring progressing to NAFLD with more severe outcomes in the lactational HFD challenged offspring.

2021-08-14 | GSE182071 | GEO

Effect of lactational high fat diet and metformin on mid-lactation murine mammary gland gene expression

Project description:Maternal health and diet can have important consequences for offspring nutrition and metabolic health. Signals are communicated from the mother to the infant during lactation through milk via macronutrients, hormones and bioactive molecules. In this study we designed experiments to probe the mother-milk-infant triad in the condition of normal maternal health and upon exposure to high fat diet (HFD) with or without concurrent metformin exposure. We examined maternal characteristics, milk composition and offspring metabolic parameters on postnatal day 16, prior to offspring beginning to wean. We found that lactational HFD increased maternal adipose tissue, mammary gland adipocytes, and altered milk lipid composition causing a higher amount of n-6 long chain fatty acids and lower n-3. Offspring of HFD dams were heavier with more body fat during suckling. Metformin exposure decreased maternal glucose and several amino acids. Offspring of met dams were smaller during suckling. Gene expression in the lactating mammary glands was impacted to a greater extent by metformin but both metformin and HFD altered genes related to muscle contraction, indicating that these genes may be more susceptible to lactational stressors. Our study demonstrates the impact of common maternal exposures during lactation on milk composition, mammary gland function and offspring growth with metformin having little capacity to recuse from the effects of a maternal HFD during lactation.

2021-06-04 | GSE176118 | GEO

Effect of lactational high fat diet on offspring liver RNA expression

Project description:Effect of lactational high fat diet on offspring liver RNA expression

| PRJNA754400 | ENA

High-Fat-Diet

Project description:High Fat Diet Experiment SD rats fed either an AIN93G-based low fat diet or an AIN93G-based high fat diet. Keywords: ordered

2006-01-01 | GSE2226 | GEO

Effect of high-fat diet exposure on mouse sperm RNA m6A modified expression profile

Project description:To further investigate the effect of high-fat diet on m6A modified expression profiles of mouse sperm RNA, we used whole-genome microarray expression profiles as a discovery platform to identify differential m6A modified genes under high-fat diet exposure. Male mice were fed normal chow (C) or 60% high-fat diet (HFD) from 5 weeks to 15 weeks old, and then sperm were obtained for Arraystar m6A-mRNA&lncRNA Epitranscriptomic Microarray. Results showed that hyper-methylated mRNAs were involved in multiple biological processes, including the "reproductive process," "gamete generation," and "spermatogenesis".

2023-12-22 | GSE241195 | GEO

Mouse muscle mitochondrial proteome changes in high fat diet vs. low fat diet

Project description:We investigated remodeling of the mitochondrial proteome to determine mechanisms of changes to lipid oxidation following high-fat feeding. C57BL/6J mice consumed either a high-fat diet (HFD, 60% fat) or low fat diet (LFD, 10% fat) for 12 weeks. Mice were fasted 4 hours then anaesthetized by sodium pentobarbital for tissue collection. A mitochondrial-enriched fraction was prepared from gastrocnemius muscles and underwent proteomic analysis by high-resolution mass spectrometry.

2018-04-12 | MSV000082272 | MassIVE

Effect of lactational high fat diet and metformin on mid-lactation murine mammary gland gene expression

Project description:Effect of lactational high fat diet and metformin on mid-lactation murine mammary gland gene expression

| PRJNA734938 | ENA

Mice livers: high fat diet versus high fat diet (HF) supplemented with pirfenidone (HFP)

Project description:Mice livers: high fat diet versus high fat diet (HF) supplemented with pirfenidone (HFP)

| PRJNA1149047 | ENA

Lactational exposure to high fat diet

Project description:To understand how gonadal adpose tissue is altered via maternal HFD feeding, we fed dams a 60% HFD only during weaning. These data are from the offspring, both control and HFD fed male mice

2023-12-08 | GSE227337 | GEO

Transcriptome in Rat liver, 3 months after 7 weeks of control diet, high fat diet or heat-mositure-treated high fat diet

Project description:In the present study, we designed a 7-week rat model, consuming high-fat diet or heat-misture-treated high fat diet. The liver was used for microarray analyses. Transcriptome profiling reveal that high-fat diet with or with out heat-moisture treatment induced different transcriptome changes, mainly on lipid metabolism and inflammation.

2023-08-08 | GSE226305 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data