Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Metabolic and transcriptomic signatures of the acute psychological stress response in the mouse brain

ABSTRACT: Metabolic and transcriptomic signatures of the acute psychological stress response in the mouse brain

PROVIDER: PRJNA945006 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23869771.fastq.gz	Fastqsanger.gz
	SRR23869772.fastq.gz	Fastqsanger.gz
	SRR23869773.fastq.gz	Fastqsanger.gz
	SRR23869774.fastq.gz	Fastqsanger.gz
	SRR23869775.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Metabolic and transcriptomic signatures of the acute psychological stress response in the mouse brain

Project description:The acute stress response triggers various physiological responses such as energy mobilization to meet metabolic demands. However, the underlying molecular changes in the brain remain largely obscure. Here, we use a brief water avoidance stress (WAS) to elicit an acute stress response in mice. By employing RNA-sequencing and metabolomics profiling, we investigate the acute stress-induced molecular changes in the mouse whole brain. Aberrant expression of 60 genes was detected in the brain tissues of WAS-exposed mice. Functional analyses showed that the aberrantly expressed genes were enriched in various processes such as superoxide metabolism. In our global metabolomic profiling, total 43 brain metabolites were significantly altered by acute WAS. Metabolic pathways upregulated from WAS-exposed brain tissues relative to control samples included lipolysis, eicosanoid biosynthesis, and endocannabinoid synthesis. Acute WAS also elevated levels of branched-chain amino acids, 5-aminovalerates, 4-hydroxy-nonenal-glutathione, as well as mannose, suggesting complex metabolic changes in the brain. The observed molecular events in the present study provide a valuable resource that can help us better understand how acute psychological stress impacts neural functions.

2023-03-20 | GSE227416 | GEO

Acute psychological stress induces short-term variable immune response

Project description:Analysis of gene expression in leukocytes taken from 13 participants 1 week before or after the skydive (baseline), before boarding the airplane (pre-boarding), at landing and 1 h after the parachute jump (1 h landing). Results identify a subset of genes expressed by natural killer cells that are upregulated in leukocytes in response to acute psychological stress.

2015-12-01 | GSE69172 | GEO

Metabolic and Transcriptomic Signatures of the Acute Psychological Stress Response in the Mouse Brain.

Project description:Acute stress response triggers various physiological responses such as energy mobilization to meet metabolic demands. However, the underlying molecular changes in the brain remain largely obscure. Here, we used a brief water avoidance stress (WAS) to elicit an acute stress response in mice. By employing RNA-sequencing and metabolomics profiling, we investigated the acute stress-induced molecular changes in the mouse whole brain. The aberrant expression of 60 genes was detected in the brain tissues of WAS-exposed mice. Functional analyses showed that the aberrantly expressed genes were enriched in various processes such as superoxide metabolism. In our global metabolomic profiling, a total of 43 brain metabolites were significantly altered by acute WAS. Metabolic pathways upregulated from WAS-exposed brain tissues relative to control samples included lipolysis, eicosanoid biosynthesis, and endocannabinoid synthesis. Acute WAS also elevated the levels of branched-chain amino acids, 5-aminovalerates, 4-hydroxy-nonenal-glutathione as well as mannose, suggesting complex metabolic changes in the brain. The observed molecular events in the present study provide a valuable resource that can help us better understand how acute psychological stress impacts neural functions.

| S-EPMC10052811 | biostudies-literature

Human psychological stress plasma

Project description:Blood plasma was collected from 9 naval aviation students 24 hours prior to and no more than 20 minutes after Modular Egress Training (psychological stressor).

2009-12-01 | PRD000158 | Pride

Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast

Project description:Psychological stress interferes with bone metabolism, in which miRNAs may play an important role. To gain an insight into skeletal alterations under psychological stress, sRNA sequencing(sRNA-seq) was performed.

2024-12-14 | GSE253504 | GEO

Single-cell transcriptome profiling implicates the psychological stress-induced disruption of spermatogenesis

Project description:Male infertility has become a global problem. And psychological stress has been proven to be an important cause of male infertility. In this work, we constructed a terrified-sound stress model in SD rats and performed single-cell RNA sequencing of the testicular tissues from the post-stressed and normal rats. Through the comparative analysis of the gene expression patterns of the 11,744 rat testicular cells, we revealed the potential mechanism by which terrified-sound induced psychological stress affects spermatogenesis and ultimately leads to reproductive impairment in male rats. This will provide a theoretical basis for the study of psychological stress on male reproductive impairments for other animals and humans, and further find the therapeutic targets for male infertility caused by psychological stress.

2024-10-08 | GSE233950 | GEO

Increased CP gateway activity under psychological stress leads to recruitment of non-encephalitogenic T cells into the brain

Project description:Knockdown of Glucocorticoid receptor at the choroid plexus in the context of psychological stress leads to the recruitment of T cells into the brain. These T cells show a non-encephalitogenic pattern of T cell associated gene expression.

2019-04-03 | GSE125586 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation [ColonBulkseq]

Project description:Mental health profoundly impacts inflammatory responses in the body. This is particularly apparent in inflammatory bowel disease (IBD), where psychological stress is associated with disease flares. Here, we discover a critical role for the enteric nervous system (ENS) in mediating the aggravating effect of chronic stress on intestinal inflammation. We find that chronically elevated levels of glucocorticoids drive the generation of an inflammatory subset of enteric glia that promotes monocyte- and TNF-mediated colitis via CSF1. Additionally, glucocorticoids cause transcriptional immaturity in enteric neurons, acetylcholine deficiency, and dysmotility via TGFβ2. We verify the connection between the psychological state, intestinal inflammation, and dysmotility in two cohorts of human IBD patients. Together, these findings offer a mechanistic explanation for the impact of the brain on peripheral inflammation, define the ENS as a relay between psychological stress and gut inflammation, and suggest that stress management could serve as a valuable component of IBD care.

2023-05-25 | GSE229320 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation [SnRNASeq_ENS]

2023-05-25 | GSE229322 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation [ScRNASeqCD45seq]

2023-05-25 | GSE229321 | GEO