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Chronic hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch2]

ABSTRACT: Chronic hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch2]

PROVIDER: PRJNA945403 | ENA |

REPOSITORIES: ENA

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Chronic hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch2]

Project description:Purpose: To identify the gene expression change under chronic hypoxia on HBE cells. Methods: bulk RNA-seq was performed on primary human bronchial epithelial cells (HBE) that were cultured on air-liquid interface (ALI) condition and treated under normoxia or hypoxia (1% O2) for 5days. Results: inflammatory cytokines, collagen degradation, and angiogenic genes were upregulated under chronic hypoxia.

2023-08-22 | GSE227501 | GEO

Hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch1]

Project description:Hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch1]

| PRJNA945402 | ENA

Hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch1]

Project description:Purpose: To identify the gene expression change under hypoxia on HBE cells. Methods: bulk RNA-seq was performed on primary human bronchial epithelial cells (HBE) that were cultured on air-liquid interface (ALI) condition and treated under normoxia or hypoxia (1% O2) for 6hr, 24hr, and 5days. Results: hypoxia-related genes were significantly upregulated under hypoxia including EGLN3.

2023-08-22 | GSE227502 | GEO

Cellular response to hypoxia on human bronchial epithelial culture [scRNA-Seq CAP]

Project description:Purpose: To identify the cell types change and gene expression change under hypoxia on HBE cells. Methods: The primary human bronchial epithelial cells (HBE) were cultured on air-liquid interface (ALI) conditions. After 4 weeks, the cells were cultured under normoxic, symmetrical hypoxic (3.5% O2), or asymmetrical hypoxic (3.5% O2 basolateral with apical cap ~ 1% O2) conditions for 5 days. The cells were dissociated with Accutase solution and proceeded to scRNA-seq. Results: Asymmetrical hypoxic cells showed more hypoxia-related responses than symmetrical hypoxic cells.

2023-08-22 | GSE227586 | GEO

human bronchial epithelial culture

Project description:human bronchial epithelial culture

| PRJNA945863 | ENA

Cellular response to hypoxia on human bronchial epithelial culture [scRNA-Seq]

Project description:Purpose: To identify the cell types change and gene expression change under hypoxia on HBE cells. Methods: The primary human bronchial epithelial cells (HBE) were cultured on air-liquid interface (ALI) conditions. After 4 weeks, the cells were cultured under normoxic or hypoxic (1% O2) conditions for 6h or 5days. The cells were dissociated with Accutase solution and proceeded to scRNA-seq. Results: Hypoxia did not induce any hypoxia-specific cell types, however, all cell types upregulated hypoxia-related, and senescence-related genes and downregulated cell proliferation genes.

2023-08-22 | GSE227508 | GEO

Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro [bulkRNA-seq]

Project description:Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro [bulkRNA-seq]

| PRJNA797245 | ENA

Cardiac organoid model of human myocardial infarction (batch2)

Project description:Cardiac organoid model of human myocardial infarction (batch2)

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Acute and Chronic Environmental Tobacco Smoke Condensate Exposure to Primary Human Bronchial Epithelial Cells

Project description:The goal was to assess global gene expression changes in primary human bronchial epithelial cells exposed to environmental tobacco smoke (ETS) condensate. ETS-C was standardized by HPLC analysis and two timepoints of exposure in two different donor bronchial epithelial cell populations were assessed. These findings demonstrate that even short exposure (4.5 h) to ETS is sufficient to induce a stress response, as reflected by decreased antioxidant levels, induced HSP family members, and modulation of the family of glutathione metabolism enzymes in primary human lung cells. Upon longer exposures (48 h) with ETS-condensate, bronchial epithelial cells arrest at the G2/M phase of the cell cycle. Taken together, these data support a stress-induced state in primary human bronchial epithelial cells that culminates in cell cycle arrest. Keywords: time course, comparative, stress response

2006-12-25 | GSE4234 | GEO

Tsc2 coordinates differentiation [bulkRNA-seq]

Project description:Tsc2 coordinates differentiation [bulkRNA-seq]

| PRJNA954865 | ENA