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Chronic hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch2]

ABSTRACT: Chronic hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch2]

PROVIDER: PRJNA945403 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23879662_1.fastq.gz	Fastqsanger.gz
	SRR23879662_2.fastq.gz	Fastqsanger.gz
	SRR23879663_1.fastq.gz	Fastqsanger.gz
	SRR23879663_2.fastq.gz	Fastqsanger.gz
	SRR23879664_1.fastq.gz	Fastqsanger.gz

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Chronic hypoxic response for human bronchial epithelial culture [bulkRNA-Seq batch2]

Project description:Purpose: To identify the gene expression change under chronic hypoxia on HBE cells. Methods: bulk RNA-seq was performed on primary human bronchial epithelial cells (HBE) that were cultured on air-liquid interface (ALI) condition and treated under normoxia or hypoxia (1% O2) for 5days. Results: inflammatory cytokines, collagen degradation, and angiogenic genes were upregulated under chronic hypoxia.

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Project description:Purpose: To identify the gene expression change under hypoxia on HBE cells. Methods: bulk RNA-seq was performed on primary human bronchial epithelial cells (HBE) that were cultured on air-liquid interface (ALI) condition and treated under normoxia or hypoxia (1% O2) for 6hr, 24hr, and 5days. Results: hypoxia-related genes were significantly upregulated under hypoxia including EGLN3.

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