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Transcriptomic landscape of the anterior thalamic nuclei of the mouse

ABSTRACT: Transcriptomic landscape of the anterior thalamic nuclei of the mouse

PROVIDER: PRJNA945930 | ENA |

REPOSITORIES: ENA

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Transcriptomic landscape of the anterior thalamic nuclei of the mouse

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Transcriptomic landscape of the anterior thalamic nuclei of the mouse [Xenium]

Project description:Transcriptomic landscape of the anterior thalamic nuclei of the mouse [Xenium]

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Project description:We profiled the transcriptome of 22 thalamic nuclei. Nuclei were retrogradely labeled from their forebrain target areas, microdissected and fluorescent cells pooled. Anterograde tracing was used when identification of nuclear boundaries was ambiguous. We found that thalamic nuclei share a common axis of variance closely linked to the mediolateral spatial axis of thalamus. This axis was enriched in functionally relevant genes such as neurotransmitter receptors and ion channels, and was closely linked to functional and morphological properties of the neurons.

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Developmental trajectories of thalamic nuclei revealed by single-cell transcriptome profiling and Shh perturbation

Project description:The thalamus is the principal information hub of the vertebrate brain, with essential roles in sensory and motor information processing, attention, and memory. The complex array of thalamic nuclei develops from a restricted pool of neural progenitors. We apply longitudinal single-cell RNA-sequencing and regional abrogation of Sonic hedgehog (Shh) to map the developmental trajectories of thalamic progenitors, intermediate progenitors, and post-mitotic neurons as they coalesce into distinct thalamic nuclei. These data reveal that the complex architecture of the thalamus is established early during embryonic brain development through the coordinated action of four cell differentiation lineages derived from Shh-dependent and independent progenitors. We systematically characterize the gene expression programs that define these thalamic lineages across time and demonstrate how their disruption upon Shh depletion causes pronounced locomotor impairment resembling infantile Parkinson’s disease. These results reveal key principles of thalamic development and provide mechanistic insights into neurodevelopmental disorders resulting from thalamic dysfunction.

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