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The Rfg1 and Bcr1 transcription factors regulate acidic pH-induced filamentous growth in Candida albicans

ABSTRACT: The Rfg1 and Bcr1 transcription factors regulate acidic pH-induced filamentous growth in Candida albicans

PROVIDER: PRJNA946283 | ENA |

REPOSITORIES: ENA

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The Rfg1 and Bcr1 transcription factors regulate acidic pH-induced filamentous growth in Candida albicans

Project description:To investigate the function of Rfg1 in sensing acidic pH and regulating filamentation in C. albicans, we performed the global gene expression profile analysis of WT and rfg1/rfg1 mutant.We reveal that Rfg1 is an essential acidic pH sensor in C. albicans. Rfg1 regulates filamentous growth in acidic pH condition via co-regulation of Rim101-Phr1 pathway, cAMP signaling pathway,and the transcription factors Bcr1, Efg1, Flo8, and Hgc1.

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