Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Multiomics analysis of HIF-stabilization in primary renal tubular cells [RNA-Seq]

ABSTRACT: Multiomics analysis of HIF-stabilization in primary renal tubular cells [RNA-Seq]

PROVIDER: PRJNA947180 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Multiomics analysis of HIF-stabilization in primary renal tubular cells

Project description:Multiomics analysis of HIF-stabilization in primary renal tubular cells

| PRJNA947174 | ENA

Multiomics analysis of HIF-stabilization in primary renal tubular cells [RNA-Seq]

Project description:The activation of hypoxia-inducible transcription factors (HIF) leading to the expression of hundreds of target genes is a fundamental mechanism in acute and chronic kidney disease, mediating protective but possibly harmful effects. Furthermore, dysregulation of the HIF pathway in chronic kidney disease causes renal anemia through insufficient erythropoietin (EPO) induction in interstitial cells. RNA-seq analysis was performed in human primary renal tubular cells to analyse the effect of HIF stabilization on the expression of genes in tubular cells. ATAC-seq and HIF-CHIP-seq complement the data to analyse transcription factor binding and chromatin configuration changes.

2023-05-05 | GSE227848 | GEO

Multiomics analysis of HIF-stabilization in primary renal tubular cells [ChIP-Seq]

2023-05-05 | GSE227823 | GEO

Multiomics analysis of HIF-stabilization in primary renal tubular cells [ATAC-Seq]

2023-05-05 | GSE227821 | GEO

Multiomics analysis of HIF-stabilization in primary renal tubular cells [ATAC-Seq]

Project description:Multiomics analysis of HIF-stabilization in primary renal tubular cells [ATAC-Seq]

| PRJNA947178 | ENA

Multiomics analysis of HIF-stabilization in primary renal tubular cells [ChIP-Seq]

Project description:Multiomics analysis of HIF-stabilization in primary renal tubular cells [ChIP-Seq]

| PRJNA947177 | ENA

mRNA expression analysis in primary renal tubular cells.

Project description:Activation of hypoxia-inducible transcription factors (HIF) leading to expression of hundred of target genes is a fundamental mechanism in acute and chronic kidney disease mediating protective but also possibly harmful effects. Furthermore, dysregulation of the HIF pathway in chronic kidney disease causes renal anemia through insufficient induction of erythropoietin (EPO) in interstitial cells. Hence, pharmacological compounds to treat renal anemia by stabilizing HIF have recently been introduced to the clinical practice. RNA-seq analysis was performed in primary renal tubular cells to analyse the effect of HIF stabilization on the expression of pathogenic Mucin1 (MUC1) variants. This study links the regulation of the kidney-disease gene MUC1 with the HIF-pathway in renal tubular cells.

2023-06-07 | GSE224177 | GEO

Open Chromatin and HIF-binding in renal tubular cells

Project description:Open Chromatin and HIF-binding in renal tubular cells

| PRJNA393644 | ENA

Multiomics analysis of HIF-stabilization in primary renal tubular cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-05 | GSE227849 | GEO

Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock

Project description:Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock

| PRJNA892713 | ENA