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MAPT expression is regulated by long-range interactions with cis-regulatory elements [ChIP-seq]

ABSTRACT: MAPT expression is regulated by long-range interactions with cis-regulatory elements [ChIP-seq]

PROVIDER: PRJNA948133 | ENA |

REPOSITORIES: ENA

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MAPT expression is regulated by long-range interactions with cis-regulatory elements [ChIP-seq]

Project description:Tau is encoded by MAPT and abnormal aggregates of tau are a hallmark of a group of neurodegenerative diseases called tauopathies. MAPT is lowly expressed in neural progenitor cells (NPCs), but it is more highly expressed in oligodendrocytes, astrocytes, and neurons that derive from NPCs. This expression switch at differentiation suggests that MAPT expression is controlled by transcription factors and cis-regulatory elements specific to these differentiated cell types, including neurons.

2023-04-12 | GSE228116 | GEO