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ScRNA-seq analysis of tumor-infiltrating CD45+ cells from sitagliptin-treated mice

ABSTRACT: scRNA-seq analysis of tumor-infiltrating CD45+ cells from sitagliptin-treated mice

PROVIDER: PRJNA948366 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23956661_1.fastq.gz	Fastqsanger.gz
	SRR23956661_2.fastq.gz	Fastqsanger.gz
	SRR23956662_1.fastq.gz	Fastqsanger.gz
	SRR23956662_2.fastq.gz	Fastqsanger.gz

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scRNA-seq analysis of tumor-infiltrating CD45+ cells from sitagliptin-treated mice

Project description:Dendritic cell (DC)-mediated antigen presentation is essential for the priming and activation of tumor-specific T cells. However, few drugs that specifically manipulate DC functions are available. Here, we observed that DCs initiated a distinct transcriptional program during antigen presentation. We utilized a network-based approach to screen for DC-targeting therapeutics. Sitagliptin, an oral gliptin widely used for type 2 diabetes, was identified as a drug that targets DCs. In mouse models, sitagliptin inhibited tumor growth by enhancing DC-mediated antigen presentation, leading to better T cell activation.

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Project description:Expression data for tumor-infiltrating CD45+ cells

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Project description:The purpose of this study was to determine the effect of EZH2 inhibitor (EZH2i) PF-06821497 on CD45+ cells isolated from MC38 tumors at day 17 post implantation. Mice were either treated for 7 days prior to endpoint or 16 days prior to endpoint with the EZH2i or with vehicle control. CD45+ cells were isolated and scRNA-Seq was performed on cells

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