Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profile at single cell level of Wild type and Plagl1 knock out retina at P7

ABSTRACT: Gene expression profile at single cell level of Wild type and Plagl1 knock out retina at P7

PROVIDER: PRJNA948461 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23958428.fastq.gz	Fastqsanger.gz
	SRR23958429.fastq.gz	Fastqsanger.gz
	SRR23958430.fastq.gz	Fastqsanger.gz
	SRR23958431.fastq.gz	Fastqsanger.gz
	SRR23958432.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Gene expression profile at single cell level of Wild type and Plagl1 knock out retina at P7

Project description:Plagl1 controls Muller glial cells proliferation in the retina. We used single cell RNA sequencing (scRNA-seq) to analyze the prolirative state of Muller glial cells and identify the signals that might be involved in this process

2024-03-24 | GSE228191 | GEO

Characterization of the transcriptomic profile of Plagl1+/-pat retina

Project description:Retinal damage triggers reactive gliosis in Müller glia across vertebrate species, but only in regenerative animals, such as teleost fish, do Müller glia initiate repair; proliferating and undergoing neurogenesis to replace lost cells. We found that Plagl1, a maternally imprinted gene, is dynamically regulated in reactive Müller glia post-insult, with transcript levels transiently increasing before stably declining. To study Plagl1 retinal function, we examined Plagl1+/-pat null mutants postnatally, revealing defects in retinal architecture, visual signal processing and a reactive gliotic phenotype. Plagl1+/-pat Müller glia proliferate ectopically and give rise to inner retinal neurons and photoreceptors. Transcriptomic and ATAC-seq profiles revealed similarities between Plagl1+/-pat retinas and neurodegenerative and injury models, including an upregulation of pro-gliogenic and pro-proliferative pathways, such as Notch, not observed in wild-type retinas Plagl1 is thus an essential component of the transcriptional regulatory networks that retain mammalian Müller glia in quiescence.

2021-05-06 | GSE173942 | GEO

Characterization of the transcriptomic profile of Plagl1+/-pat retina

Project description:Characterization of the transcriptomic profile of Plagl1+/-pat retina

| PRJNA727582 | ENA

Characterization of the chromatin accessibility profile of Plagl1+/-pat retina

2021-05-05 | GSE173853 | GEO

Characterization of the chromatin accessibility profile of Plagl1+/-pat retina

Project description:Characterization of the chromatin accessibility profile of Plagl1+/-pat retina

| PRJNA727312 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of control, SETD6 Knock-out, SETD3 knock-out and SETD6+SETD3 knock-out HeLa cells Transcriptomes

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of control, SETD6 Knock-out, SETD3 knock-out and SETD6+SETD3 knock-out HeLa cells Transcriptomes

| PRJNA819059 | ENA

ARRDC4 knock out Mouse Heart Analysis

Project description:ARRDC4 knock out Mouse Heart Analysis

| PRJNA773414 | ENA

anaerobic knock-out

Project description:Six different knock-out strains' expression data under anaerobic condition Keywords: parallel sample

2004-03-10 | GSE1107 | GEO

aerobic knock-out

Project description:Six different knock-out strains' expression data under aerobic condition Keywords: parallel sample

2004-03-10 | GSE1106 | GEO

DcgA knock-out experiment in Dictyostelium discoideum

Project description:DcgA knock-out experiment in Dictyostelium discoideum