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The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice

ABSTRACT: The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice

PROVIDER: PRJNA948838 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23972412_1.fastq.gz	Fastqsanger.gz
	SRR23972412_2.fastq.gz	Fastqsanger.gz
	SRR23972413_1.fastq.gz	Fastqsanger.gz
	SRR23972413_2.fastq.gz	Fastqsanger.gz
	SRR23972414_1.fastq.gz	Fastqsanger.gz

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The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice

Project description:This work defines the temperature sensitive myokine Musclin as a negative regulator of adipose thermogenesis that exacerbates the deterioration of metabolic health in male mice through antagonizing Tfr1/PKA signaling in beige adipocytes, and thus provides a framework for the therapeutic targeting of this endocrine pathway.

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