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Comparision of transcriptomes between murine WT type 1 conventional DCs to XCR1-deficient type 1 conventional DCs

ABSTRACT: Comparision of transcriptomes between murine WT type 1 conventional DCs to XCR1-deficient type 1 conventional DCs

PROVIDER: PRJNA949620 | ENA |

REPOSITORIES: ENA

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Comparision of transcriptomes between murine WT type 1 conventional DCs to XCR1-deficient type 1 conventional DCs

Project description:We sought to compare the overall transcriptomic differences between TLR stimulated WT and XCR1-deficient type 1 conventional DCs. In addition, we also wanted to investigate functional role of XCR1 signaling in WT type 1 conventional DCs by treating recombinant murine XCL1, a ligand of XCR1 to these cells as well

2023-06-01 | GSE228392 | GEO

Analysis of transcriptomes of WT & XIST deficient type 1 conventional DCs in mice

Project description:To investigate the cooperative function of Xist (X-inactive specific transcript) in type 1 conventional DCs in relation to TLR & XCR1 signaling

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XCR1 expression distinguishes human conventional dendritic cells type 1 with full effector functions from their immediate precursors

Project description:Dendritic cells (DCs) are major regulators of innate and adaptive immune responses. DCs can be classified into plasmacytoid DCs and conventional DCs (cDCs) type 1 and 2. Murine and human cDC1 share the mRNA expression of XCR1. Murine studies indicated a specific role of the XCR1-XCL1 axis in the induction of immune responses. Here, we describe that human cDC1 can be distinguished into XCR1- and XCR1+ cDC1 in lymphoid as well as non-lymphoid tissues. Steady state XCR1+ cDC1 display a pre-activated phenotype compared to XCR1- cDC1. Upon stimulation, XCR1+ cDC1, but not XCR1- cDC1, secreted high levels of inflammatory cytokines as well as chemokines. This was associated with enhanced activation of NK cells mediated by XCR1+ cDC1. Moreover, XCR1+ cDC1 excelled in inhibiting replication of Influenza A virus. Further, under DC differentiation conditions, XCR1- cDC1 developed into XCR1+ cDC1. After acquisition of XCR1 expression, XCR1- cDC1 secreted comparable level of inflammatory cytokines. Thus, XCR1 is a marker of terminally differentiated cDC1 that licenses the antiviral effector functions of human cDC1, while XCR1- cDC1 seem to represent a late immediate precursor of cDC1.

2023-07-31 | GSE237715 | GEO

Analysis of chromatin accessibility of WT & XIST deficient type 1 conventional DCs in female mice

Project description:To investigate the cooperative function of Xist (X-inactive specific transcript) in type 1 conventional DCs in relation to TLR & XCR1 signaling

2024-05-24 | GSE267828 | GEO

Comparative analysis of WT and XCR1 KO type 1 conventional dendritic cells [array]

Project description:XCR1 is known as a signature receptor of type 1 conventional dendritic cells To compare the transcriptomic differences of WT and XCR1 deficient type 1 conventional dendritic cells, we conducted microarry using type 1 conventional dendritic cells from WT and XCR1 KO mice

2024-05-20 | GSE267410 | GEO

XCR1+ type 1 conventional dendritic cells drive liver pathology in Non-Alcoholic Steatohepatitis.

Project description:XCR1+ type 1 conventional dendritic cells drive liver pathology in Non-Alcoholic Steatohepatitis.

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Comparative analysis of WT and XCR1 KO type 1 conventional dendritic cells [array]

Project description:Comparative analysis of WT and XCR1 KO type 1 conventional dendritic cells [array]

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Analysis of transcriptomes of WT & XIST deficient type 1 conventional DCs in mice

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XCR1+ type 1 conventional dendritic cells drive liver pathology in Non-Alcoholic Steatohepatitis [scRNA-seq]

Project description:XCR1+ type 1 conventional dendritic cells drive liver pathology in Non-Alcoholic Steatohepatitis [scRNA-seq]

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