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Gene expression analysis in untreated adult zebrafish livers (~1 year older): wild-type TAB14 compared to as3mt-/- mutants

ABSTRACT: Gene expression analysis in untreated adult zebrafish livers (~1 year older): wild-type TAB14 compared to as3mt-/- mutants

PROVIDER: PRJNA951411 | ENA |

REPOSITORIES: ENA

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Gene expression analysis in untreated adult zebrafish livers (~1 year older): wild-type TAB14 compared to as3mt-/- mutants

Project description:This study was carried out to compare the changes in basal gene expression in livers of ~1 year old zebrafish adults in response to whole body mutation of the arsenite methyltransferase gene (as3mt) - 8 bp deletion in exon 3 resulting in a loss of function.

2023-07-07 | GSE228751 | GEO

Determining the effects of hepatic As3mt overexpression on the response to arsenic in the liver of zebrafish larvae

Project description:This study was carried out to compare changes in gene expression in 120 hpf livers that overexpress as3mt in hepatocytes between after 24-hour exposure to 1.0 and 1.5 mM iAs. Tg(fabp10a:As3mt) untreated = CL 1 AS3MT 0; Tg(fabp10a:As3mt) iAs treated = CL 1 AS3MT 1 or CL 1 AS3MT 1.5.

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Transcritomic analysis in untreated and sodium arsenite treated (96-120 hours post fertilization; hpf) in pooled (12-15) zebrafish larval livers 5 days post fertilization (dpf): wild-type TAB5 compared to as3mt mutant larvae

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Transcription profiling of vastus lateralis muscle from healthy young (21-31 year old) and older (62-77 year old) men

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FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC

Project description:Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation (LT); however, the potential mechanism remains unclear. Here, we demonstrated older livers exhibit a higher degree of ferroptosis during HIRI. Inhibiting ferroptosis significantly attenuated older HIRI. Mass spectrometry revealed fat mass and obesity-associated gene (FTO) was downregulated in older livers, especially during HIRI. Overexpressing FTO ameliorated older HIRI by inhibiting ferroptosis. Mechanistically, ACSL4 and TFRC, two key positive contributors of ferroptosis, were targets of FTO. The mitigating effect of FTO on older HIRI required the inhibition of Acsl4 and Tfrc mRNA stability in a m6A-dependent manner. Furthermore, we demonstrated nicotinamide mononucleotide (NMN) could upregulate FTO demethylase activity to suppress ferroptosis and attenuate older HIRI. Collectively, these findings revealed an FTO-ACSL4/TFRC regulatory pathway that contributes to the pathogenesis of older HIRI, providing insight into the clinical translation of strategies related to the demethylase activity of FTO in order to improve graft function after older donor LT.

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Analysis of the transcriptome of undifferentiated SH-SY5Y neuroblastoma cells following AS3MT knockout with CRISPR/Cas9.

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Transcritomic analysis in untreated and sodium arsenite treated (96-120 hours post fertilization hpf) in pooled (12-15) zebrafish larval livers 5 days post fertilization (dpf): wild-type TAB5 compared to as3mt mutant larvae

Project description:Transcritomic analysis in untreated and sodium arsenite treated (96-120 hours post fertilization hpf) in pooled (12-15) zebrafish larval livers 5 days post fertilization (dpf): wild-type TAB5 compared to as3mt mutant larvae

| PRJNA951412 | ENA

Gene expression analysis by RNA-seq on control 5 dpf zebrafish livers

Project description:This study was carried out to compare potential changes in the gene expression in 5 dpf livers between untreated, 1.0 and 1.5mM iAs exposures.

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Gene expression profile of wild type, PiZ and PiZ/Chop-/- mouse livers at two different ages

Project description:To investigate the role of CHOP in the pathogenesis of liver disease due to Z alpha-1 antitrypsin in juvenile and older mice, we performed Quant-seq experiments at 6 and 36 weeks of age in wild type, PiZ and PiZ/Chop-/- mouse livers

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