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Single cell gene expression profiling of slow cycling and actively dividing mouse glioblastoma (GBM) cells isolated based on H2B-GFP label retention.

ABSTRACT: Single cell gene expression profiling of slow cycling and actively dividing mouse glioblastoma (GBM) cells isolated based on H2B-GFP label retention.

PROVIDER: PRJNA951632 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24046100_1.fastq.gz	Fastqsanger.gz
	SRR24046100_2.fastq.gz	Fastqsanger.gz
	SRR24046101_1.fastq.gz	Fastqsanger.gz
	SRR24046101_2.fastq.gz	Fastqsanger.gz
	SRR24046102_1.fastq.gz	Fastqsanger.gz

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Single cell gene expression profiling of slow cycling and actively dividing mouse glioblastoma (GBM) cells isolated based on H2B-GFP label retention.

Project description:A slow cycling, dormant cell state is thought to contribute to the therapeutic resistance of GBM tumour cells, yet not much is known about the biology of this slow-cycling cell population in GBM. By using somatic mouse model of GBM, combined with the inducible H2B-GFP label retention system, we isolated dormant tumour cells from their in vivo niches, and characterised them by single cell RNA sequencing.

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RNA-sequencing of cycling PKH26-Negative cells and PKH26-Positive label retaining quiescent cancer stem cells from colon cancer patient-derived organoids

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Identification of slow-cycling cells in Ewing sarcoma

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Histone H2B^3-32, H2B K->G, H2B^3-37, and H2B^30-37 mutations

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