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Engrailed-1 Promotes Pancreatic Cancer Metastasis [CUT&RUN]

ABSTRACT: Engrailed-1 Promotes Pancreatic Cancer Metastasis [CUT&RUN]

PROVIDER: PRJNA951669 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24047005_1.fastq.gz	Fastqsanger.gz
	SRR24047005_2.fastq.gz	Fastqsanger.gz
	SRR24047006_1.fastq.gz	Fastqsanger.gz
	SRR24047006_2.fastq.gz	Fastqsanger.gz
	SRR24047007_1.fastq.gz	Fastqsanger.gz

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Engrailed-1 Promotes Pancreatic Cancer Metastasis [CUT&RUN]

Project description:Engrailed-1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, we report that EN1 is aberrantly expressed in a subset of pancreatic ductal adenocarcinoma (PDA) patients with poor outcomes. EN1 predominantly repressed its target genes through direct binding to gene enhancers and promoters, implicating a role in the cellular response to the stimulation of mesenchymal cell properties. Gain- and loss-of-function experiments demonstrated that EN1 promoted PDA transformation and metastasis in vitro and in vivo. Our findings nominate the targeting of EN1 and downstream pathways in aggressive PDA.

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Engrailed-1 Promotes Pancreatic Cancer Metastasis

Project description:Engrailed-1 Promotes Pancreatic Cancer Metastasis

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Engrailed-1 Promotes Pancreatic Cancer Metastasis [RNA-Seq]

Project description:Engrailed-1 Promotes Pancreatic Cancer Metastasis [RNA-Seq]

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Engrailed-1 Promotes Pancreatic Cancer Metastasis [RNA-Seq]

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