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Transcriptomic changes in the medial prefrontal cortex of juvenile rat offspring after induced birth with oxytocin

ABSTRACT: Transcriptomic changes in the medial prefrontal cortex of juvenile rat offspring after induced birth with oxytocin

PROVIDER: PRJNA952158 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24061206_1.fastq.gz	Fastqsanger.gz
	SRR24061206_2.fastq.gz	Fastqsanger.gz
	SRR24061207_1.fastq.gz	Fastqsanger.gz
	SRR24061207_2.fastq.gz	Fastqsanger.gz
	SRR24061208_1.fastq.gz	Fastqsanger.gz

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Transcriptomic changes in the medial prefrontal cortex of juvenile rat offspring after induced birth with oxytocin

Project description:We report changes in the medial prefrontal cortical transcriptome of male and female rat offspring after induced birth with oxytocin using RNA-seq analysis.

2023-04-05 | GSE228913 | GEO

Maternal oxytocin treatment at birth increases epigenetic age in male offspring [array]

Project description:Rates of oxytocin use to induce or augment labor are increasing in the United States with little understanding of the impact on offspring development. Using a prairie vole animal model, we have shown that oxytocin administered to mothers can reach offspring brains with long lasting impacts on the development of social behaviors. Here, we examine the epigenetic and transcriptomic consequences of oxytocin exposure during birth in juvenile male offspring. First, we show that male offspring exposed to oxytocin at birth have increased epigenetic age compared to the saline exposed group. We also find 900 differentially methylated CpG sites (annotated to 589 genes), with 2 CpG sites (2 genes) remaining significant after correction for multiple comparisons. Differentially methylated CpG sites are involved in regulation of gene expression and neurodevelopment. Using RNA-sequencing we find 217 nominally differentially expressed genes (p<0.05) in nucleus accumbens, a brain region involved in reward circuitry and social behavior, including 6 genes that remain significantly differentially expressed after corrections for multiple comparisons. Finally, we show that maternal oxytocin administration leads to widespread alternative splicing in the nucleus accumbens. These results indicate that oxytocin exposure during birth has long lasting epigenetic consequences in the brain and warrant further investigation of how oxytocin administration impacts development and behavior throughout the lifespan.

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Juvenile fluoxetine evoked gene expression changes in the rat medial prefrontal cortex

Project description:To understand the consequences of chronic exposure to fluoxetine during juvenile life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood. To understand the consequences of chronic exposure to fluoxetine during juvenile life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood.

2024-06-30 | GSE270731 | GEO

Maternal oxytocin treatment at birth increases epigenetic age in male offspring

Project description:Maternal oxytocin treatment at birth increases epigenetic age in male offspring

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Maternal oxytocin treatment at birth increases epigenetic age in male offspring [array]

Project description:Maternal oxytocin treatment at birth increases epigenetic age in male offspring [array]

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Postnatal fluoxetine evoked gene expression changes in the rat medial prefrontal cortex

Project description:To understand the consequences of chronic exposure to fluoxetine during postnatal life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood. To understand the consequences of chronic exposure to fluoxetine during postnatal life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood.

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Transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of alcohol-preferring and nonpreferring rats

Project description:Animal models provide opportunity to study neurobiological aspects of human alcoholism. Changes in gene expression have been implicated in mediating brain function, including reward system and addiction. The current study aimed to identify novel genes that may underlie ethanol preference. Microarray analysis comparing gene expression in nucleus accumbens (NAc), hippocampus (HP) and prefrontal medial cortex (mPFC) was performed in two rat strains selected for extreme levels of ethanol preference - Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP). The identified candidate genes may underlie differential ethanol preference in rat model of alcoholism. This is analysis of 18 RNA samples, including 9 technical replicates. Two strains of rats selected for extreme levels of ethanol preference (low preferring WLP and high preferring WHP) were compared. Three brain areas (nucleus accumbens, prefrontal medial cortex and hippocampus) were studied. For each brain area, 6 RNA samples (including 3 technical replicates) were analyzed. Each RNA sample consist of of equal amounts of total RNA from 3 male rats. Comparisons: Nucleus accumbens of WHP vs. Nucleus accumbens of WLP; Prefrontal medial cortex of WHP vs. Prefrontal medial cortex of WLP; Hippocampus of WHP vs. Hippocampus of WLP. 3 biological replicates in each comparison.

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Maternal oxytocin treatment at birth increases epigenetic age in male offspring [RNA-seq]

Project description:Maternal oxytocin treatment at birth increases epigenetic age in male offspring [RNA-seq]

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Juvenile fluoxetine evoked gene expression changes in the rat medial prefrontal cortex

Project description:Juvenile fluoxetine evoked gene expression changes in the rat medial prefrontal cortex

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