Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pseudomonas anuradhapurensis strain:UFPIB5-8A

ABSTRACT: Pseudomonas anuradhapurensis strain:UFPIB5-8A Genome sequencing

PROVIDER: PRJNA952222 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Bacillus cereus strain:8A

Project description:Bacillus cereus strain:8A Genome sequencing and assembly

| PRJNA351721 | ENA

Brevundimonas vesicularis strain:PL22-8A

Project description:Brevundimonas vesicularis strain:PL22-8A Genome sequencing

| PRJNA922345 | ENA

Alternative splicing of LSD1+8a is mediated by SRRM4 in Neuroendocrine Prostate Cancer

Project description:Neuroendocrine prostate cancer (NEPC) is the most virulent subtype. Currently, there is an urgent need to identify new biomarkers and therapeutic targets in NEPC. The splicing factor SRRM4 was previously demonstrated to be highly expressed in NEPC, to promote expression of genes linked to neuroendocrine differentiation and cancer progression, and to promote alternate splicing of genes, including REST. One of REST’s binding protein is lysine specific demethylase 1 (LSD1). Importantly, a transcript variant of LSD1 called LSD1+8a is expressed in neuronal tissues and promotes neuronal gene expression. However, there was no information about LSD1+8a’s importance in prostate cancer. Using adenocarcinoma and NEPC patient-derived xenografts and clinical specimens, we determined that LSD1+8a was expressed exclusively in NEPC. Furthermore, LSD1+8a expression was significantly correlated with elevated mRNA expression of SRRM4. Using SRRM4-overexpressing prostate cancer cell lines, we determined that alternative splicing of LSD1+8a is directly mediated by SRRM4 and that LSD1+8a and SRRM4 co-regulate a unique program of cancer-promoting genes that is not regulated by canonical LSD1. Our findings demonstrate that measurement of LSD1+8a expression is a promising NEPC biomarker and suggest that targeting LSD1+8a in NEPC may be a useful strategy to block expression of genes linked to cancer progression.

2020-05-19 | GSE132062 | GEO

Bacillus pacificus strain:KVCMST-8A-12

Project description:Bacillus pacificus strain:KVCMST-8A-12 Genome sequencing and assembly

| PRJNA656513 | ENA

Leptothoe sp. ISB3NOV94-8A

Project description:Leptothoe sp. ISB3NOV94-8A Genome sequencing

| PRJNA1047161 | ENA

Fowl adenovirus 8a strain:SDQD | isolate:broiler

Project description:Fowl adenovirus 8a strain:SDQD | isolate:broiler Genome sequencing and assembly

| PRJNA1046706 | ENA

Fusarium pseudograminearum strain:WZ-8A

Project description:Fusarium pseudograminearum strain:WZ-8A Transcriptome or Gene expression

| PRJNA776550 | ENA

Fusarium pseudograminearum strain:WZ-8A

Project description:Fusarium pseudograminearum strain:WZ-8A Transcriptome or Gene expression

| PRJNA772598 | ENA

Neurospora crassa strain:2489x8790 8a

Project description:Neurospora crassa FGSC2489 X. crassa FGSC8790 8a Resequencing genome sequencing

| PRJNA334636 | ENA

DNA Methyltransferase M.PaeTBCFI in a chronically adapted Pseudomonas aeruginosa strain

Project description:Pseudomonas aeruginosa is an opportunistic pathogen which causes acute and chronic infections that are difficult to treat. Comparative genomic analysis has showed a great genome diversity among P. aeruginosa clinical strains and revealed important regulatory traits during chronic adaptation. While current investigation of epigenetics of P. aeruginosa is still lacking, understanding the epigenetic regulation may provide biomarkers for diagnosis and reveal important regulatory mechanisms. The present study focused on characterization of DNA methyltransferases (MTases) in a chronically adapted P. aeruginosa clinical strain TBCF10839. Single-molecule real-time sequencing (SMRT-seq) was used to characterize the methylome of TBCF. RCCANNNNNNNTGAR and TRGANNNNNNTGC were identified as target motifs of DNA MTases, M.PaeTBCFI and M.PaeTBCFII, respectively.

2023-07-22 | GSE209530 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data