Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular reframing of fibroblasts during resolution of arthritis [scRNA 2]

ABSTRACT: Molecular reframing of fibroblasts during resolution of arthritis [scRNA 2]

PROVIDER: PRJNA952270 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24067526_1.fastq.gz	Fastqsanger.gz
	SRR24067526_2.fastq.gz	Fastqsanger.gz
	SRR24067527_1.fastq.gz	Fastqsanger.gz
	SRR24067527_2.fastq.gz	Fastqsanger.gz
	SRR24067528_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 52

Similar Datasets

Molecular reframing of fibroblasts during resolution of arthritis [scRNA]

Project description:Molecular reframing of fibroblasts during resolution of arthritis [scRNA]

| PRJNA952267 | ENA

Molecular reframing of fibroblasts during resolution of arthritis [scRNA]

Project description:Fibroblasts are key orchestrators of inflammation. Little is known whether these cells change phenotype during resolution of inflammation. We adopted a method to visualise fibroblast activation during inflammation in humans in vivo, which is based on a fibroblast activation protein (FAP) tracer detected by positron emission tomography (PET). While tracer accumulation was high in active arthritis, it decreased significantly after TNF- and IL-17A inhibition. Biopsy-based scRNA-seq analyses in experimental arthritis demonstrated that FAP signal reduction reflected a phenotypic switch from pro-inflammatory MMP3+/IL6+ fibroblasts (high FAP internalisation) to pro-resolving CD200+DKK3+ fibroblasts (low FAP internalisation). Spatial transcriptomics of human joints revealed that pro-resolving niches of CD200+DKK3+ fibroblasts clustered with innate lymphoid cells (ILC)2, whereas MMP3+/IL6+ fibroblasts were co-localised with inflammatory immune cells. CD200+DKK3+ fibroblasts stabilised the ILC2 phenotype and induced resolution of arthritis via CD200/CD200R1 pathway. Taken together, these data suggest a dynamic molecular regulation of the mesenchymal compartment during resolution of inflammation.

2024-01-16 | GSE228980 | GEO

Molecular reframing of fibroblasts during resolution of arthritis

Project description:Molecular reframing of fibroblasts during resolution of arthritis

| PRJNA952269 | ENA

Molecular reframing of fibroblasts during resolution of arthritis [scRNA 2]

2024-01-16 | GSE228981 | GEO

Molecular reframing of fibroblasts during resolution of arthritis [RNA]

Project description:Molecular reframing of fibroblasts during resolution of arthritis [RNA]

| PRJNA952240 | ENA

Molecular reframing of fibroblasts during resolution of arthritis [Visium]

Project description:Molecular reframing of fibroblasts during resolution of arthritis [Visium]

| PRJNA952258 | ENA

Molecular reframing of fibroblasts during resolution of arthritis [RNA]

2024-01-16 | GSE228953 | GEO

Molecular reframing of fibroblasts during resolution of arthritis [Visium]

2024-01-16 | GSE228972 | GEO

Molecular reframing of fibroblasts during resolution of arthritis

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-16 | GSE228982 | GEO

scRNA-seq of lung CD140a+ mesenchymal cells (fibroblasts) from CD140a-EGFP reporter mice

Project description:To investigate the heterogeneity of lung CD140a+ mesenchymal cells (fibroblasts) and identify the specific lung fibroblast subset, we purified CD140a+ lung cells using CD140a-EGFP reporter mice for a higher-resolution scRNA-seq.

2022-07-19 | E-MTAB-11875 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data