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Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing diet change

ABSTRACT: Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing diet change

PROVIDER: PRJNA952796 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24088200_1.fastq.gz	Fastqsanger.gz
	SRR24088200_2.fastq.gz	Fastqsanger.gz
	SRR24088201_1.fastq.gz	Fastqsanger.gz
	SRR24088201_2.fastq.gz	Fastqsanger.gz
	SRR24088202_1.fastq.gz	Fastqsanger.gz

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Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing diet change

Project description:Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich in fat over plant-based diets, especially for short periods of time. The health consequences of this short-term consumption of energy-dense nutrients remain still unclear. We found that every short-term, reiterated switches to feast diets mimicking our social eating behavior, breached the potential buffering effect of the intestinal microbiota and deeply reorganized the immunological architecture of mucosa-associated lymphoid tissues. The first dietary switch was sufficient to induce transient mucosal immune depression and suppress systemic, antigen-specific immunity leading to higher susceptibility to Salmonella Typhimurium and Listeria monocytogenes infections. This was explained by a reduction of CD4+ T cell metabolic fitness and cytokine production due to impaired mTOR activity in response to withdrawal of microbial provision of fiber metabolites. Reintroducing dietary fiber efficiently rewired T cell metabolism and restored both mucosal and systemic CD4+ T cell functions and immunity. Finally, dietary intervention study in human volunteers confirmed the impact of short-term dietary switches on human CD4+ T cell functionality. This work reveals that short-term nutritional changes cause a drastic yet transient depression of both mucosal and systemic immunity, creating windows of opportunities for pathogenic infections.

2023-07-11 | GSE229088 | GEO

Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing diet change (baseline)

2023-07-11 | GSE236786 | GEO

Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing diet change (baseline)

Project description:Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing diet change (baseline)

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Synchronized response of CD4+ T cells to short-term dietary changes - CD4+ T cell RNA sequencing

2023-07-11 | GSE229087 | GEO

Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing after Salmonella infection

2023-07-11 | GSE229086 | GEO

Synchronized response of CD4+ T cells to short-term dietary changes - CD4+ T cell RNA sequencing

Project description:Synchronized response of CD4+ T cells to short-term dietary changes - CD4+ T cell RNA sequencing

| PRJNA952795 | ENA

Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing after Salmonella infection

Project description:Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing after Salmonella infection

| PRJNA952794 | ENA

Synchronized response of CD4+ T cells to short-term dietary changes leads to windows of mucosal and systemic immune depression

Project description:Synchronized response of CD4+ T cells to short-term dietary changes leads to windows of mucosal and systemic immune depression

| PRJNA952788 | ENA

Dietary short-term fiber interventions in arthritis

Project description:Dietary short-term fiber interventions in arthritis patients increase systemic SCFA levels and regulate inflammation

| PRJEB40439 | ENA

Short-term low calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults

Project description:OBJECTIVE Diet intervention in obese adults is the first strategy to induce weight loss and to improve insulin sensitivity. We hypothesized that improvements in insulin sensitivity after weight loss from a short-term dietary intervention tracks with alterations in expression of metabolic genes and abundance of specific lipid species. RESEARCH DESIGN AND METHODS Eight obese, insulin resistant, non-diabetic adults were recruited to participate in a three-week low calorie diet intervention study (1000 kcal/day). Fasting blood samples and vastus lateralis skeletal muscle biopsies were obtained before and after the dietary intervention. Clinical chemistry and measures of insulin sensitivity were determined. Unbiased microarray gene expression and targeted lipidomic analysis of skeletal muscle was performed. RESULTS Body weight was reduced, insulin sensitivity (HOMA-IR) was enhanced, and serum insulin concentration and blood lipid (triglyceride, cholesterol, LDL and HDL) levels were improved after dietary intervention. Gene set enrichment analysis of skeletal muscle revealed that oxidative phosphorylation and inflammatory processes were among the most enriched KEGG-pathways identified after dietary intervention. mRNA expression of PDK4 and MLYCD increased, while SCD decreased in skeletal muscle after dietary intervention. Dietary intervention altered the intramuscular lipid profile of skeletal muscle, with changes in content of phosphatidylcholine and triglyceride species among the pronounced. CONCLUSIONS Short-term diet intervention and weight loss in obese adults alters metabolic gene expression and reduces specific phosphatidylcholine and triglyceride species in skeletal muscle, concomitant with improvements in clinical outcomes and enhanced insulin sensitivity.

2019-02-05 | GSE103682 | GEO

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