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The effect of Aryl hydrocarbon receptor (AHR) inhibitor CH-223191 on differentiation of human colon organoids

ABSTRACT: The effect of Aryl hydrocarbon receptor (AHR) inhibitor CH-223191 on differentiation of human colon organoids

PROVIDER: PRJNA952947 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24093428.fastq.gz	Fastqsanger.gz
	SRR24093429.fastq.gz	Fastqsanger.gz
	SRR24093430.fastq.gz	Fastqsanger.gz
	SRR24093431.fastq.gz	Fastqsanger.gz
	SRR24093432.fastq.gz	Fastqsanger.gz

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The effect of Aryl hydrocarbon receptor (AHR) inhibitor CH-223191 on differentiation of human colon organoids

Project description:To investigate the effect of AHR deficiency on organoid differentiation or in stem cell state we performed RNA-seq of human colon organoids treated with CH-223191 or DMSO in stem cell conditions or during differentiation

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Effect of aryl hydrocarbon receptor (Ahr) gene knockout on expression profiles of murine hematopoietic stem cells

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Project description:Disruption of the lung endothelial-epithelial cell barrier during respiratory virus infection causes cell and fluid accumulation in the air spaces and compromises vital gas exchange function. Endothelial cell dysfunction is known to exacerbate tissue damage; however, it is unclear whether the lung endothelium engages in tissue-protective activity during viral infection. Here we show that the environmental sensor aryl hydrocarbon receptor (AHR) is predominantly active in endothelial cells and protects against influenza-induced lung damage. Endothelial-specific AHR deletion caused increased vascular leakage in air spaces and enhanced influenza-induced lung tissue pathology. Global expression profiling revealed limited AHR-dependent regulation of vessels in the steady-state lung. However, following influenza-induced tissue damage and inflammation, AHR engages tissue-protective programmes in endothelia and prevents a dysplastic keratinised and apoptotic signature in the airways of infected lungs.

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Effect of bone marrow-specific aryl hydrocarbon receptor (Ahr) gene knockout on expression profiles of hematopoietic stem cells from young and old mice.

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Chromatin immunoprecipitation (ChIP) of aryl hydrocarbon receptor (AHR) in mouse colon stem cells

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