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ABSTRACT: Lycium barbarum L polysaccharide ameliorates DSS-induced ulcerative colitis by improving gut barrier function and modulating gut microbiota

PROVIDER: PRJNA953837 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24114234_1.fastq.gz	Fastqsanger.gz
	SRR24114234_2.fastq.gz	Fastqsanger.gz
	SRR24114235_1.fastq.gz	Fastqsanger.gz
	SRR24114235_2.fastq.gz	Fastqsanger.gz
	SRR24114236_1.fastq.gz	Fastqsanger.gz

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Effect of Lycium barbarum polysaccharide-glycoprotein(LBP) on irradiated HaCaT cells

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Label-free quantitative data dependent (DDA) nano-LC-MS/MS analysis of proteomic changes in the mesenteric lymph harvested from healthy (control) and DSS-fed mice models of colitis

Project description:The gastrointestinal mucosa constitutes a critical barrier where millions of microbes and environmental antigens can interact with the host immune system. Intestinal barrier defects have been linked to a broad range of pathological states, including autoimmune, cancer and neurodegenerative diseases. Accordingly, it has been proposed as a leading therapeutic target. This research aimed to investigate the qualitative and quantitative changes in the proteomes of pre- and post-nodal mesenteric lymph at steady state and following inflammatory disruption of the intestinal barrier which could lead to the identification the antigenic and inflammatory load draining to the mesenteric lymph nodes, in both healthy and DSS-feed mice models of colitis and inflammatory bowel disease (IBD). To achieve this goal, we employed label-free quantitative (LFQ) bottom-up proteomics analysis of pre- and post-nodal mesenteric lymph. To map changes in the lymph composition following inflammatory damage, mice were fed dextran sulfate sodium (DSS), a sulfated polysaccharide which causes ulcerative colitis-like pathologies and as an additional inflammatory effect on the ileum mucosa. DSS-mediated inflammation in mice mediated significant qualitative and quantitative proteomic changes mapped to the release of damage-associated molecular pattern (DAMPS) in the afferent lymph, mostly generated from the damaged epithelia. In addition, molecular signatures of colitis/enteritis, organ injury and gastrointestinal inflammation were further found by the proteomics analysis. Importantly, enzymes normally confined to the gut, such as chymotrypsin, peptidases, phospholipases, elastases were mapped in the afferent lymph, consistent with the proteolysis and lipolysis observed following breaking down of the gut barrier.

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Project description:Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Gut Microbiota

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Lycium-barbarum-root

Project description:Chemotyping dataset of n-butanol peptide extract of Lycium barbarum root

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The study of precise nutrition intervention for colorectal cancer targeting intestinal flora

Project description:Interventions: experimental group 1:Lycium barbarum polysaccharides;Experimental group 2:probiotics;experimental group 3:probiotics+ Lycium barbarum polysaccharides;Control group:placebo Primary outcome(s): Short chain fatty acids;IL-1 beta;IL-6;IL-4;IL-10;Immune interferon;tumor necrosis factor;MUC-2;Bcl-xL;NF-kB;IkB alpha;CRP;SIgA;postoperative abdominal pain;Flora richness;Flora diversity;Flora structure Study Design: Parallel

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Dextran sodium sulfate treatment of wild type and Pirc rats alters colonic normal tissue gene expression

Project description:Dextran sodium sulfate (DSS) causes inflammation in the gut similar to ulcerative colitis in humans. Patients with ulcerative colitis have increased risk of developing colon cancer. We sought to determine which genes are altered in the normal colonic epithelium, and which changes depend on the Pirc mutation. 97 day old (ACIxF344)F1 wild type and Pirc male rats either untreated or given 4% DSS in the drinking water from 40-47 and 54-61 days of age, housed in 12 hour light:12 dark, ad lib feeding. Normal colonic tissue was collected from the distal colon at 97 days of age.

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Transcriptomic analyses between Lycium barbarum and Lycium ruthenicum

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