Project description:To investigate the effect of Burkholderia fungorum (BF) on cholangiocarcinoma cells, we treated the cell lines with bacterial supernatant and performed transcriptome sequencing. By transcriptome sequencing, we quantified the differentially expressed genes in control and experimental groups. The results of GO and KEGG functional enrichment analysis showed that the differentially expressed genes were mainly involved in some biological processes of metabolism and amino acid synthesis. We inferred that the transcriptome characterization can help us understand the relationship between bacterium and tumor cell metabolism.
