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Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation (RNA-Seq)

ABSTRACT: Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation (RNA-Seq)

PROVIDER: PRJNA955208 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24155200_1.fastq.gz	Fastqsanger.gz
	SRR24155200_2.fastq.gz	Fastqsanger.gz
	SRR24155201_1.fastq.gz	Fastqsanger.gz
	SRR24155201_2.fastq.gz	Fastqsanger.gz
	SRR24155202_1.fastq.gz	Fastqsanger.gz

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Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation

Project description:Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation

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Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation (ChIP-Seq)

Project description:Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation (ChIP-Seq)

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Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation (ChIP-Seq)

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Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation

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Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation (RNA-Seq)

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Project description:Experience-dependent plasticity of synapses modulates information processing in neural circuits and is essential for cognitive functions. The genome, via non-coding enhancers, was proposed to control information processing and circuit plasticity by regulating experience-induced transcription of genes that modulate specific sets of synapses. To test this idea, here we analyze the cellular and circuit functions of the genomic mechanisms that control the experience-induced transcription of Igf1 (Insulin-like growth factor 1) in VIP interneurons (INs) in the adult visual cortex. We find that two sensory-induced enhancers selectively and cooperatively drive the activity-induced transcription of Igf1 to thereby promote GABAergic inputs onto VIP INs and to homeostatically control the ratio between excitation and inhibition (E/I-ratio), and that this restricts neural activity in VIP INs and principal excitatory neurons and maintains spatial frequency tuning. Thus, enhancer-mediated activity-induced transcription maintains sensory processing in the adult cortex via homeostatic modulation of E/I-ratio.

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