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Effect of CDDO-2P-Im Treatment in Fibroblast Cells

ABSTRACT: Effect of CDDO-2P-Im Treatment in Fibroblast Cells

PROVIDER: PRJNA955658 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24165864_1.fastq.gz	Fastqsanger.gz
	SRR24165864_2.fastq.gz	Fastqsanger.gz
	SRR24165865_1.fastq.gz	Fastqsanger.gz
	SRR24165865_2.fastq.gz	Fastqsanger.gz
	SRR24165866_1.fastq.gz	Fastqsanger.gz

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Effect of CDDO-2P-Im Treatment in Fibroblast Cells

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Project description:Alzheimer’s disease (AD) is the most common etiology of dementia. The transcription factor NF-E2-related factor 2 (NRF2) induces the expression of genes encoding phase II detoxification and antioxidant genes. NRF2 is regulated by Kelch-like ECH-associated protein 1 (KEAP1), and the KEAP1-NRF2 system is the key regulatory system involved in cytoprotection. To examine whether pharmacological induction of NRF2 expression alleviates AD phenotypes in vivo, we employed two AD mouse models, i.e., AppNL-G-F/NL-G-F (AppNLGF) and APPV717I::TAUP301L (APP/TAU) mice. As the synthetic oleanane triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11-dien-28-oyl)] (CDDO)-4(-pyridin-2-yl)-imidazole (CDDO-2P-Im) exhibits strong NRF2-inducing activity, in this study, we treated AD model mice with CDDO-2P-Im.

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