Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chemotherapy induces cell plasticity controlling plasticity increases therapeutic response.

ABSTRACT: Chemotherapy induces cell plasticity controlling plasticity increases therapeutic response.

PROVIDER: PRJNA955789 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24174914_1.fastq.gz	Fastqsanger.gz
	SRR24174914_2.fastq.gz	Fastqsanger.gz
	SRR24174915_1.fastq.gz	Fastqsanger.gz
	SRR24174915_2.fastq.gz	Fastqsanger.gz
	SRR24174916_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response.

Project description:One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours, which leads to tumour recurrence and, ultimately, patient death To investigated this we analyze plasticity of chemotherapy-resistant cells

2024-04-09 | GSE229761 | GEO

Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy Response

Project description:Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy Response

| PRJNA1126222 | ENA

EMT-driven plasticity prospectively increases cell-cell variability to promote therapeutic adaptation in breast cancer

Project description:EMT-driven plasticity prospectively increases cell-cell variability to promote therapeutic adaptation in breast cancer

| PRJNA1098856 | ENA

Impact of EMT-driven plasticity on phenotypic diversity dynamics under chemotherapy [spontaneous]

Project description:Impact of EMT-driven plasticity on phenotypic diversity dynamics under chemotherapy [spontaneous]

| PRJNA1098864 | ENA

Impact of EMT-driven plasticity on phenotypic diversity dynamics under chemotherapy [organoids]

Project description:Impact of EMT-driven plasticity on phenotypic diversity dynamics under chemotherapy [organoids]

| PRJNA1098863 | ENA

Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy Response

Project description:Methionine restriction sensitizes A549 cells with and without LKB1 to chemotherapy

2024-07-19 | GSE270333 | GEO

Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity controlling organ speciation

Project description:Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity controlling organ speciation

| PRJNA881317 | ENA

Tepoxalin increases chemotherapy efficacy in drug-resistant breast cancer cells overexpressing the multidrug transporter gene ABCB1

Project description:Tepoxalin increases chemotherapy efficacy in drug-resistant breast cancer cells overexpressing the multidrug transporter gene ABCB1

| PRJNA725471 | ENA

Targeting hepatic IRE1a for Treating GDF15-driven Anorexia in Chemotherapy

Project description:Anorexia and other side effects of chemotherapy significantly limit the clinical applications of these chemotherapeutic agents, with underlying mechanisms still unclear. A growing body of research reveals that elevated levels of circulating GDF15 after chemotherapy are essential in initiating anorexia and other side effects by activating GFRAL+ neurons in the brainstem. However, the full array of context-dependent transcriptional regulators controlling Gdf15 expression remains to be defined. This study reports that chemotherapy drugs acutely stimulate liver GDF15 production via selective activation of the hepatic stress sensor IRE1α, thereby controlling circulating GDF15 levels. Genetic ablation of hepatic IRE1α reduces circulating GDF15 and alleviates anorexia and body weight loss following chemotherapy drug treatments in tumor-bearing mice. Mechanistically, chemotherapy drugs activate hepatic IRE1α RNase activity to produce the active form of the transcription factor XBP1 to promotes the expression of Gdf15 gene in hepatocytes. Moreover, treatment with pharmacological IRE1α RNase inhibitor effectively suppresses liver Gdf15 expression and circulating GDF15 levels, resulting in improvements in chemotherapy-induced anorexia and body weight loss. Our results reveal a stress-responsive mechanism that mediates communication between the liver and brain. This mechanism can be targeted pharmacologically to alleviate anorexic side effects that accompany chemotherapy-induced body weight loss.

2024-04-22 | GSE235695 | GEO

Impact of EMT-driven plasticity on phenotypic diversity dynamics under chemotherapy [spontaneous]

Project description:Triple negative breast cancer (TNBC) is the most lethal breast cancer subgroup, as lack of targeted therapies and drug resistance reduce survival rates. Cellular plasticity enables cells to adapt non-genetically and overcome therapeutic pressure, thereby embodying a critical clinical hurdle. The epithelial-mesenchymal transition (EMT) is an example of phenotypic reprogramming linked to plasticity, drug resistance and metastasis. However, its exact impact on population diversity under therapeutic pressure is unknown. Here, we used single cell transcriptomics to investigate phenotypic diversity dynamics upon drug treatment in two human in vitro models of TNBC plasticity.

2024-12-04 | GSE263729 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data