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Exploration of lncRNA/circRNA-miRNA-mRNA networks in patients with chronic atrophic gastritis in plateau areas

ABSTRACT: Exploration of lncRNA/circRNA-miRNA-mRNA networks in patients with chronic atrophic gastritis in plateau areas

PROVIDER: PRJNA956555 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24197471_1.fastq.gz	Fastqsanger.gz
	SRR24197471_2.fastq.gz	Fastqsanger.gz
	SRR24197472_1.fastq.gz	Fastqsanger.gz
	SRR24197472_2.fastq.gz	Fastqsanger.gz
	SRR24197473_1.fastq.gz	Fastqsanger.gz

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Exploration of lncRNA/circRNA-miRNA-mRNA networks in patients with chronic atrophic gastritis in plateau areas [miRNA]

Project description:Higher incidence of chronic atrophic gastritis (CAG) is generally considered a precancerous lesion of gastric cancer (GC). Therefore, the early diagnosis and treatment of CAG, especially in Tibetan Plateau areas, play an important role in the prevention of GC. The atrophic and non-atrophic gastric mucosal tissue samples from 7 patients with chronic gastritis (CG) and cancer tissue samples from 3 patients with GC were collected. High-throughput sequencing was performed to identify the differentially expressed in lncRNAs, circRNAs, miRNAs, and mRNAs, followed by the construction of competitive endogenous RNA (ceRNA) regulatory networks (lncRNA/circRNA-miRNA-mRNA network) in CAG. Those differentially expressed mRNAs with the same expression trend in both CAG and GC were further identified. Two datasets (GSE153224 and GSE163416), involving data in non-Tibetan Plateau areas, were used to further screen out plateau-specific mRNAs in CAG, followed by identification of the plateau-specific and ferroptosis related mRNAs. GO and KEGG enrichment analysis were performed to investigate the biological functions of plateau-specific mRNAs in CAG. This study may provide useful information for identifying potential biomarkers for the diagnosis of CAG.

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Exploration of lncRNA/circRNA-miRNA-mRNA networks in patients with chronic atrophic gastritis in plateau areas [lncRNA]

Project description:Exploration of lncRNA/circRNA-miRNA-mRNA networks in patients with chronic atrophic gastritis in plateau areas [lncRNA]

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Exploration of lncRNA/circRNA-miRNA-mRNA networks in patients with chronic atrophic gastritis in plateau areas [miRNA]

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Next Generation Sequencing Facilitates Quantitative Analysis of atrophic gastritis and atrophic gastritis receivng PEEPA-P5 antrum epithelial Transcriptomes

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Project description:Helicobacter pylori colonization of the human stomach is a strong risk factor for gastric cancer. To investigate H. pylori-induced gastric molecular alterations, we used a Mongolian gerbil model of gastric carcinogenesis. Histologic evaluation revealed varying levels of atrophic gastritis (a premalignant condition characterized by parietal and chief cell loss) in H. pylori-infected animals, and transcriptional profiling revealed a loss of markers for these cell types. We then assessed the spatial distribution and relative abundance of proteins in the gastric tissues using imaging mass spectrometry and liquid chromatography with tandem mass spectrometry (LC-MS/MS). We detected striking differences in protein content of corpus and antrum tissues. 492 proteins were preferentially localized to the corpus in uninfected animals. The abundance of 91 of these proteins was reduced in H. pylori-infected corpus tissues exhibiting atrophic gastritis compared to infected corpus tissues with non-atrophic gastritis or uninfected corpus tissues; these included numerous proteins with metabolic functions. Fifty proteins localized to the corpus in uninfected animals were diffusely delocalized throughout the stomach in infected tissues with atrophic gastritis; these included numerous proteins with roles in protein processing. Corresponding alterations were not detected in animals infected with a H. pylori ∆cagT mutant (lacking Cag type IV secretion system activity). These results indicate that H. pylori can cause loss of proteins normally localized to the gastric corpus as well as diffuse delocalization of corpus-specific proteins, resulting in marked changes in the normal gastric molecular partitioning into distinct corpus and antrum regions.

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Exploration of lncRNA/circRNA-miRNA-mRNA networks in patients with chronic atrophic gastritis in plateau areas

Project description:This SuperSeries is composed of the SubSeries listed below.

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