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Responder vs non-responder in vivo tumours in response to poly(I:C) loaded hydrogel (CT26)

ABSTRACT: Responder vs non-responder in vivo tumours in response to poly(I:C) loaded hydrogel (CT26)

PROVIDER: PRJNA956879 | ENA |

REPOSITORIES: ENA

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Responder vs non-responder in vivo tumours in response to poly(I:C) loaded hydrogel (CT26)

Project description:CT26 tumour samples taken by 90% debulking surgery, followed by treatment with poly(I:C) loaded hydrogel.

2023-06-04 | GSE229950 | GEO

Responder vs non-responder in vivo tumours in response to poly(I:C) loaded hydrogel (WEHI-164)

Project description:Responder vs non-responder in vivo tumours in response to poly(I:C) loaded hydrogel (WEHI-164)

| PRJNA958174 | ENA

Responder vs non-responder in vivo tumours in response to poly(I:C) loaded hydrogel (WEHI-164)

Project description:WEHI-164 tumour samples taken after 75% debulking surgery, followed by treatment with poly(I:C) loaded hydrogel.

2023-06-04 | GSE230269 | GEO

Towards optimized tissue regeneration: A new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate

Project description:Introduction: Autologous platelet concentrates (APC) are pro-angiogenic and can promote wound healing and tissue repair, also in combination with other biomaterials. However, challenging defect situations remain demanding. 3D bioprinting of an APC based bioink encapsulated in a hydrogel could overcome this limitation with enhanced physio-mechanical interface, growth factor retention/secretion and defect-personalized shape to ultimately enhance regeneration. Methods: This study used extrusion-based bioprinting to create a novel bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate. Chemico-physical testing exhibited an amorphous structure characterized by high shape fidelity. Cytotoxicity assay and incubation of human osteogenic sarcoma cells (SaOs2) exposed excellent biocompatibility. ELISA analysis confirmed pro-angiogenic growth factor release of the printed constructs, and co-incubation with HUVECS displayed proper cell viability and proliferation. Chorioallantoic membrane (CAM) assay explored the pro-angiogenic potential of the prints in vivo. Detailed proteome and secretome analysis revealed a substantial amount and homologous presence of pro-angiogenic proteins in the 3D construct. Results: This study demonstrated a 3D bioprinting approach to fabricate a novel bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate with high shape fidelity, biocompatibility, and substantial pro-angiogenic properties. Conclusion: This approach may be suitable for challenging physiological and anatomical defect situations when translated into clinical use.

2024-06-23 | PXD050629 | Pride

Mesenchymal stem cell-loaded hydrogel improves surgical treatment for chronic cerebral ischemia

Project description:Mesenchymal stem cell-loaded hydrogel improves surgical treatment for chronic cerebral ischemia

| PRJNA1119941 | ENA

Collagen 1 Hydrogel Dynamic Loading Tests

2008-01-11 | GSE10125 | GEO

TCR variable regions transcripts of CT26-shppp2r1a and CT26-scr samples

Project description:TCR variable regions transcripts of three CT26-shppp2r1a samples and three CT26-scr samples

2021-11-20 | GSE189092 | GEO

Mesenchymal stem cell-loaded hydrogel improves surgical treatment for chronic cerebral ischemia

Project description:Chronic cerebral ischemia (CCI) results in a prolonged insufficient blood supply to the brain tissue, leading to impaired neuronal function and subsequent impairment of cognitive and motor abilities. Our previous research showed that in mice with bilateral carotid artery stenosis, the collateral neovascularization post Encephalo-myo-synangiosis (EMS) treatment could be facilitated by bone marrow mesenchymal stem cells (MSCs) transplantation. Considering the advantages of biomaterials, we synthesized and modified a gelatin hydrogel for MSCs encapsulation. We then applied this hydrogel on the brain surface during EMS operation in rats with CCI, and evaluated its impact on cognitive performance and collateral circulation.

2024-06-10 | GSE269005 | GEO

Transcription profiling of human dermal fibroblasts after 3 hours of cyclic mechanical loading compared with ni loading - collagen 1 hydrogel dynamic loading tests

Project description:Cell viability and global gene expression was anayzed from collagen 1 hydrogel scaffolds following 3 hours of cyclic mechanical loading and compared with non-loaded scaffolds. Experiment Overall Design: 6 samples are analyzed (2 sets in triplicate). The first set is the Loaded condition in which Collagen 1 hydrogels seeded with Human dermal fibroblasts underwent cyclic loading of 0.1Hz for 180 minutes at 37 degrees Celsius. The second set is the control Unloaded condition in which the Collagen 1 hydrogels seeded with Human dermal fibroblasts are incubated at 37 degrees Celsius with no loading.

2008-06-11 | E-GEOD-10125 | biostudies-arrayexpress

RNA sequencing data of CT26-shppp2r1a and CT26-scr samples

Project description:Goal: Microsatellite-instable (MSI) tumors are one of the few cancers that respond to immune checkpoint blockade (ICB); however, the mechanism of MSI status development is unclear. Here, we report that protein phosphatase 2A (PP2A) deletion or inactivation converted cold microsatellite-stable (MSS) into MSI tumors. Objectives: Using RNA sequencing data of three CT26-shppp2r1a data and a CT26-scr data, we demonstrate that these intestinal tumors display differential core driver pathways.

2021-08-26 | GSE182571 | GEO

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