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Single-cell RNA sequencing (scRNA-seq) of all IL-23R+ cell types in the small intestine of healthy mice

ABSTRACT: Single-cell RNA sequencing (scRNA-seq) of all IL-23R+ cell types in the small intestine of healthy mice

PROVIDER: PRJNA956919 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24204429.fastq.gz	Fastqsanger.gz
	SRR24204430.fastq.gz	Fastqsanger.gz
	SRR24204431.fastq.gz	Fastqsanger.gz
	SRR24204432.fastq.gz	Fastqsanger.gz

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Single-cell RNA sequencing (scRNA-seq) of all IL-23R+ cell types in the small intestine of healthy mice

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Project description:Purpose: The goals of this study are to compare RNAs bound by translating ribosomes in the presence or absence of Segmented Filamentous Bacteria (SFB) colonization of the small intestine Methods: EDTA fractions containing small intestine epithelial cells from SFB negative and SFB positive mice were harvested. TRAP assay enriching for ribosome bound fraction were enriched using anti-GFP antibodies against GFP-ribosomeL10 fusion protein. mRNA profiles were generated by deep sequencing, using Illumina HighSeq. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) and TopHat followed by CuffDiff. qRT–PCR validation was performed using SYBR Green assays. Results: SFB colonization upregulate a subset of mRNAs being translated by ribosomes. Conclusions: SFB changes small intestine epithelial cell translation profile.

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