Immune training in aged microglia [ChIP-seq]
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA957806 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR24233076_1.fastq.gz | Fastqsanger.gz | |||
| SRR24233076_2.fastq.gz | Fastqsanger.gz | |||
| SRR24233077_1.fastq.gz | Fastqsanger.gz | |||
| SRR24233077_2.fastq.gz | Fastqsanger.gz | |||
| SRR24233078_1.fastq.gz | Fastqsanger.gz |
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Project description:Immune cells, the most core part of the immune system of the whole body, could rapidly response to the change of environment. Its roles in tissue homeostasis and disease were fairly clear except brain, an immune privilege site. Previous studies had revealed the contribution of microglia, a tissue-resident macrophage, for brain development and neuronal disease. But it was currently unknown whether the other subtypes of immune cells and which of the microglia populations program their function during different stages of development. Here, we analyzed the genes expression pattern of 26,456 immune cells from the whole zebrafish brain during adult and aged stage. Our analysis uncovered the present of lymphocyte in zebrafish brain, and gradually accumulated with aging. In addition, the number of microglia were reduced bute the diversity were increased in aged brain. Collectively, our data provide insights into zebrafish brain immune cells populations that explain the distinct composition of immune cells in adult and aged brain, which might contribute to understanding the roles of immune cells in aging-associated-disease.
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