Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Historical Contingency Drives Compensatory Evolution and Rare Reversal of Phage Resistance

PROVIDER: PRJNA958383 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24258100_1.fastq.gz	Fastqsanger.gz
	SRR24258100_2.fastq.gz	Fastqsanger.gz
	SRR24258101_1.fastq.gz	Fastqsanger.gz
	SRR24258101_2.fastq.gz	Fastqsanger.gz
	SRR24258102_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 52

Similar Datasets

Project description:Historical contingency shapes adaptive radiation in Antarctic fishes

| PRJNA531677 | ENA

Rapid design of bacteriophage cocktails to suppress the burden and virulence of gut-resident carbapenem-resistant Klebsiella pneumoniae

Project description:Antibiotic use can lead to expansion of multi-drug resistant pathobionts within the gut microbiome that can cause life-threatening infections. Selective alternatives to conventional antibiotics are in dire need. Here, we describe a Klebsiella PhageBank that enables the rapid design of antimicrobial bacteriophage cocktails to treat multi-drug resistant Klebsiella pneumoniae. Using a transposon library in carbapenem-resistant K. pneumoniae, we identified host factors required for phage infection in major Klebsiella phage families. Leveraging the diversity of the PhageBank and experimental evolution strategies, we formulated combinations of phages that minimize the occurrence of phage resistance in vitro. Optimized bacteriophage cocktails selectively suppressed the burden of multi-drug resistant K. pneumoniae in the mouse gut microbiome and drove bacterial populations to lose key virulence factors that act as phage receptors. Further, phage-mediated diversification of bacterial populations in the gut enabled co-evolution of phage variants with higher virulence and a broader host range. Altogether, the Klebsiella PhageBank represents a roadmap for both phage researchers and clinicians to enable phage therapy against a critical multidrug-resistant human pathogen.

2024-10-01 | GSE272297 | GEO

Abiotic influence on phage resistance evolution

Project description:Abiotic influence on phage resistance evolution

| PRJEB51326 | ENA

Project description:Phage recombination drives evolution of spore-forming Bacilli

| PRJNA626600 | ENA

historical contingency in Escherichia coli

Project description:Contrasting effects of historical contingency on phenotypic and genomic trajectories during a two-step evolution experiment with bacteria

| PRJEB13018 | ENA

Project description:Compensatory evolution in populations with fixed or non-fixed antibiotic resistance

| PRJNA910842 | ENA

Project description:Historical contingency impacts community assembly and ecosystem function in sulfidic marine ecosystems

| PRJNA635092 | ENA

Genomic and gene-expression comparisons among phage-resistant type-IV pilus mutants of Pseudomonas syringae pathovar phaseolicola

Project description:Pseudomonas syringae pv. phaseolicola (Pph) is a significant bacterial pathogen of agricultural crops, and phage Î¦6 and other members of the dsRNA virus family Cystoviridae undergo lytic (virulent) infection of Pph, using the type IV pilus as the initial site of cellular attachment. Despite the popularity of Pph/phage Î¦6 as a model system in evolutionary biology, Pph resistance to phage Î¦6 remains poorly characterized. To investigate differences between phage Î¦6 resistant Pseudomonas syringae pathovar phaseolicola strains, we performed expression analysis of super and non piliated strains of Pseudomonas syringae to determine the genetic cause of resistance to viral infection.

2016-03-15 | E-MTAB-4053 | biostudies-arrayexpress

Project description:Historical contingency maintains biogeographic and microbially driven functional variation in a common garden experiment

| PRJNA805255 | ENA

Project description:The phage resistance evolution in K54 hypervirulent Klebsiella pneumoniae

| PRJNA1190331 | ENA