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YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function

ABSTRACT: YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function

PROVIDER: PRJNA961105 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24288981_1.fastq.gz	Fastqsanger.gz
	SRR24288981_2.fastq.gz	Fastqsanger.gz
	SRR24288982_1.fastq.gz	Fastqsanger.gz
	SRR24288982_2.fastq.gz	Fastqsanger.gz
	SRR24288983_1.fastq.gz	Fastqsanger.gz

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YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function

Project description:N6-methyladenosine (m6A) in messenger RNA (mRNA) regulates immune cells in homeostasis and in response to infection and inflammation. The function of YTHDF2 in the tumor microenvironment (TME) in these contexts has not been explored. We discovered that loss of Ythdf2 in regulatory T (Treg) cells can reduce tumor growth in mice while maintaining peripheral homeostasis. In the tumor microenvironment, Ythdf2-deficient Treg cells have impaired function and poor survival. The elevated tumor necrosis factor (TNF) signaling in the TME grants the location-specific function of YTHDF2, which participates in the feedback regulation of NF-kB signaling by accelerating the degradation of m6A-modified, NF-kB negative regulators, Nlrc3, Nfkbie, and Traf3. TME-specific regulation of Treg by YTHDF2 points to YTHDF2 as a target for anti-cancer immunotherapy, where intratumoral Treg cells can be targeted to enhance antitumor immune response, while avoiding Treg cells in the periphery to minimize undesired inflammations.

2023-06-07 | GSE230418 | GEO

YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function [RNA-seq]

2023-06-07 | GSE216959 | GEO

YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function [RIP-seq]

2023-06-07 | GSE216958 | GEO

YTHDF2/m6A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs

Project description:N6-methyladenosine (m6A) in messenger RNA (mRNA) regulates immune cells in homeostasis and in response to infection and inflammation. The function of the m6A reader YTHDF2 in the tumor microenvironment (TME) in these contexts has not been explored. We discovered that the loss of YTHDF2 in regulatory T (Treg) cells reduces tumor growth in mice. Deletion of Ythdf2 in Tregs does not affect peripheral immune homeostasis but leads to increased apoptosis and impaired suppressive function of Treg cells in the TME. Elevated tumor necrosis factor (TNF) signaling in the TME promotes YTHDF2 expression, which in turn regulates NF-κB signaling by accelerating the degradation of m6 A-modified transcripts that encode NF-κB-negative regulators. This TME-specific regulation of Treg by YTHDF2 points to YTHDF2 as a potential target for anti-cancer immunotherapy, where intratumoral Treg cells can be targeted to enhance anti-tumor immune response while avoiding Treg cells in the periphery to minimize undesired inflammations.

2023-06-06 | GSE216960 | GEO

YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function [RNA-seq]

Project description:YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function [RNA-seq]

| PRJNA896253 | ENA

YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function [RIP-seq]

Project description:YTHDF2-m6A-NF-kB axis controls anti-tumor immunity through regulating intratumoral Treg survival and function [RIP-seq]

| PRJNA896252 | ENA

An NF-kB-dependent, lineage specific transcriptional program regulates Treg identity and function [ChIP-seq]

Project description:NF-kB p65 ChIPseq revealed differential binding of p65 in Treg vs Tconv upon TCR stimulation

2017-09-13 | GSE99319 | GEO

Benchmarking NF-kB inhibitors

Project description:Benchmarking NF-kB inhibitors

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YTHDF2/m6A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs

Project description:YTHDF2/m6A/NF-κB axis controls anti-tumor immunity by regulating intratumoral Tregs

| PRJNA896248 | ENA

The effect of genetic and chemical inhibition of NF-kB subunits on the regulatory T cell (Treg) transcriptome

Project description:We report here the transcriptome analysis on murine total, resting and activated Treg cells after chemical (using the drug pentoxifylline) and genetic (using conditional KO strain) inhibition of NF-kB.

2017-09-11 | GSE82008 | GEO

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