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ABSTRACT: RME1 overexpression in Candida albicans strain SC5314

PROVIDER: PRJNA961908 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24303833_1.fastq.gz	Fastqsanger.gz
	SRR24303833_2.fastq.gz	Fastqsanger.gz
	SRR24303834_1.fastq.gz	Fastqsanger.gz
	SRR24303834_2.fastq.gz	Fastqsanger.gz
	SRR24303835_1.fastq.gz	Fastqsanger.gz

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Genome-wide location of Candida albicans transcription factor Rme1p

Project description:Rme1, a conserved transcription factor among members of the ascomycete lineage, regulates meiosis and pseudohyphal growth in baker’s yeast. The genome of the meiosis-defective fungal pathogen Candida albicans encodes a Rme1 homolog, which we previously mapped within a transcriptional circuitry that controls hyphal growth. To delineate a possible role of Rme1 in C. albicans morphogenesis, we combined genome-wide expression and location analyses of Rme1. Strikingly, Rme1 bound upstream and activated the expression of markers of chlamydosporulation, a process leading to formation of large, spherical, thick-walled cells during nutrient starvation. RME1 deletion abolished chlamydosporulation in three chlamydospore-forming Candida species, whereas its overexpression bypassed the requirement for chlamydosporulation cues and regulators, indicating that Rme1 is central to chlamydospore development. Moreover, RME1 expression levels correlated with chlamydosporulation efficiency among clinical isolates, further highlighting Rme1 importance in this process. Interestingly, RME1 displayed a biphasic pattern of expression, with a first phase independent of Rme1 function and dependent on chlamydospore-inducing cues, and a second phase depending upon Rme1 function and independent of chlamydospore-inducing cues. We suggest that Rme1 function spans from the regulation of meiosis in sexual yeasts to the control of an epigenetic switch necessary for asexual spore formation in meiosis-defective Candida species.

2020-10-07 | GSE142159 | GEO

Genome-wide expression profiling of Candida albicans transcription factor Rme1p

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Combining Genome-wide Gene Expression Analysis (RNA-seq) and Gene Editing Platform (CRISPR-Cas9) to Uncover the Selectively Pro-oxidant Activity of Aurone Compound against Candida albicans

Project description:The antifungal activity of aurones SH1009 and SH9051 against Candida albicans was investigated. A whole-genome transcriptional analysis post aurone SH1009 and SH9051 treatments on the C. albicans SC5314 strain was performed using RNA-seq technique.

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Transcriptional profiling and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans

Project description:Invasion of host tissue by the human fungal pathogen, Candida albicans is an important step during many forms of candidosis. However, not all C. albicans strains possess the same invasive and virulence properties. It is known for example that the two clinical isolates SC5314 and ATCC10231 differ in their ability to invade into host tissue and to cause infections. Strain SC5314 is invasive whereas strain ATCC10231 is non-invasive and strongly attenuated in virulence as compared to SC5314. In this study we compare the in vitro transcriptional profiles and the genotypic profiles of these two widely used laboratory strains in order to determine the principal biological and genetic properties which may govern the different potential for invasiveness and virulence. Keywords: transcriptional profiling, comparative genomic hybridisation, invasive vs. non-invasive C. albicans strain

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Project description:We perform microarray analysis of HUVECs upon stimulation with virulent wildtype C. albicans strain SC5314 or its efg1/efg1 cph1/cph1 hyphal-deficient derivative strain CAN34 to compare the gene expression profiles elicited from HUVECs in response to these strains. In addition, these responses are compared to that of TNF-alpha induced responses to determine which responses are Candida-specific. Keywords: comparison of host response to different Candida albicans morphologies

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Whole genome sequencing of tebuconazole adaptors derived in Candida albicans

Project description:Candida albicans lab strain SC5314 was exposed to tebuconazole (0.25μg/ml - 16 μg/ml). Randomly 32 adaptors were sequenced.

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Whole genome sequencing of fluconazole tolerant adaptors derived from exposure to echinocandins in Candida albicans

Project description:Candida albicans lab strain SC5314 was spread on YPD plates supplemented with echinocandins (caspofungin, anidulafungin, micafungin, rezafungin). The adaptors were tested for tolrance to fluconazole. Randomly 43 tolerant adaptors, as well as the parent SC5314, were sequenced.

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Project description:In Candida albicans, SC5314 is the wild type strain. FY1398 is Chr3 trisomy strain derived from SC5314. In this study, approximately 1 million cells of FY1398 were spread on YPD plate supplemented with 128 ug/ml brefeldin A. Randomly 18 adpators (LH40-LH57) were chosen. These adaptors were sequenced.

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Project description:Candida albicans lab strain SC5314 was daily passaged in YPD broth supplemented with fluconazole. Some fluconazole-resistant and some fluconazole-tolerant adaptors were sequenced.

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Project description:Candida albicans lab strain SC5314 was spread on YPD plates supplemented with ketoconazole (0.125-16μg/ml); Randomly 3 adaptors from each plate were sequenced.

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