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Single cell RNA-seq of 4T1-T vasculogenic mimicry-competent mammary tumors

ABSTRACT: Single cell RNA-seq of 4T1-T vasculogenic mimicry-competent mammary tumors

PROVIDER: PRJNA962056 | ENA |

REPOSITORIES: ENA

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Single cell RNA-seq of 4T1-T vasculogenic mimicry-competent mammary tumors

Project description:We have previously described a sub-clones of the 4T1 mammary carcinoma cell line that are proficient for vasculogenic mimciry (VM), namely 4T1-E and 4T1-T. In vitro assays suggest that not all cells within these lines a VM-competent. To explore subsets of cells within tumors derived from these cells that may display VM properties we utilized single cell RNA-Seq of 4T1-T mammary fat-pad tumors.

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Single cell RNA-seq of 4T1 mammary tumors treated with Axitinib

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Gene expression of osteosarcama cell line with vasculogenic mimicry phenotype

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Investigating vasculogenic mimicry in breast cancer

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Project description:Vasculogenic mimicry (VM) is an intriguing phenomenon observed in tumor masses, in which cancer cells organize themselves into capillary-like channels that closely resemble the structure and function of blood vessels. Although VM is believed to contribute to alternative tumor vascularization, the detailed regulatory mechanisms controlling these cellular processes remain poorly understood. Our study aimed to investigate the role of Early Growth Response 1 (EGR1) in regulating VM in aggressive cancer cells, specifically MDA-MB-231 triple-negative breast cancer cells.

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