Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lung epithelial cell ATAC G9ai

ABSTRACT: Lung epithelial cell ATAC G9ai

PROVIDER: PRJNA964591 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24364678_1.fastq.gz	Fastqsanger.gz
	SRR24364678_2.fastq.gz	Fastqsanger.gz
	SRR24364679_1.fastq.gz	Fastqsanger.gz
	SRR24364679_2.fastq.gz	Fastqsanger.gz
	SRR24364680_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

ATAC-seq of human lung cell types

Project description:We report the application of the assay for transposase-accessible chromatin using sequencing (ATAC-seq) for the profiling of open chromatin human primary lung cell types implicated in lung disease pathology, such as chronic obstructive pulmonary disease. We generated chromatin accessibility profiles for human primary bronchial epithelial cells, small airway epithelial cells, alveolar type II pneumocytes, and lung fibroblasts using Omni-ATAC-seq. We further profiled open chromatin in a commonly used bronchial epithelial cell line (16HBE14o-) to evaluate the correlation with primary cell profiles and confirm the technical improvements using Omni-ATAC-seq vs Fast-ATAC-seq. We used these profiles to evaluate the enrichment of COPD risk variants in lung-specific open chromatin regions (OCRs) and generated cell type-specific regulatory predictions for >6,500 variants corresponding to 82 COPD GWAS loci.

2021-04-02 | GSE152779 | GEO

Lung epithelial cell ATAC G9ai

Project description:The goal of the experiment was to assess the changes in chromatin accessibility in different populations of lung epithelial cells after H3K9me2 depletion via G9a inhibition

2023-10-05 | GSE231366 | GEO

Single cell ATAC-seq study of Lung epithelial cells with Il33 KO cells

Project description:Single cell ATAC-seq study of Lung epithelial cells with Il33 KO cells

| PRJNA740063 | ENA

ATAC-seq of human lung cell types

Project description:ATAC-seq of human lung cell types

| PRJNA640387 | ENA

Epigenetic basis of oncogenic-Kras mediated epithelial-cellular proliferation and plasticity [ATAC-seq]

Project description:We perfromed ATAC-seq on normal and Kras mutant mouse lung epithelial cells.

2021-12-22 | GSE183873 | GEO

mouse normal lung epithelial cell single cell RNA-seq

Project description:mouse normal lung epithelial cell single cell RNA-seq

| PRJNA510021 | ENA

McGill EMC Community projects Release 7 for cell line "lung epithelial" - samples

Project description:Complete reference epigenome (as defined by IHEC) of a lung epithelial cell line with non-small Cell Lung Adenocarcinoma

| EGAD00001007679 | EGA

Proteome analysis of mouse lung epithelial cells

Project description:Proteome analysis of lung epithelial cells of house dust mite-challenged mice. The cells were isolated from frozen tissue section by LASER microdissection.

2019-08-16 | PXD010792 | JPOST Repository

Single cell ATAC-seq study of Lung epithelial cells with Il33 KO cells

Project description:Epithelial cells are charged with protection at barrier sites, but whether this normally beneficial response might sometimes become dysfunctional still needs definition. Here we identify a pattern of imbalance marked by basal epithelial cell growth and differentiation that replaces normal airspaces in a mouse model of progressive post-viral lung disease due to Sendai virus. Single-cell and lineage-tracing technologies identify a distinct subset of basal epithelial stem cells (basal- ESCs) that extend into gas-exchange tissue to form long-term bronchiolar-alveolar remodeling regions. Moreover, this cell subset is selectively expanded by crossing a cell growth and survival checkpoint linked to the nuclear-localized alarmin IL-33 that is independent of IL-33-receptor signaling and instead connected to autocrine chromatin accessibility. This mechanism creates an activated stem-progenitor cell lineage with potential for physiological or pathological function. Thus, conditional loss of Il33 gene function in basal epithelial cells disrupts homeostasis of the epithelial barrier at skin and gut sites but also markedly attenuates post-viral disease in the lung based on down-regulation of remodeling and inflammation. We thereby identify a basal-ESC strategy to deploy innate-immune machinery that appears to overshoot the primordial goal of self- defense. The findings reveal new targets to stratify and correct chronic and often deadly post-viral disease.

2021-07-29 | GSE178711 | GEO

Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury

Project description:Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury

| PRJNA904307 | ENA