Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ChIP-seq of mouse alveolar organoids treated with bleomycin

ABSTRACT: ChIP-seq of mouse alveolar organoids treated with bleomycin

PROVIDER: PRJNA965888 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

ChIP-seq of mouse alveolar organoids treated with bleomycin

Project description:In fibrotic lung, upregulation of p53 signaling in alveolar epithelium is observed. Then, we performed p53 ChIP-seq using alveolar organoids to investigate genes directly targeted by p53 protein in bleomycin-treated p53-upregulated alveolar epithelial cells.

2023-05-07 | GSE231445 | GEO

Mouse feeder-free alveolar organoids treated by bleomycin

Project description:To investigate the direct effect of bleomycin on alveolar epithelium, feeder-free mouse alveolar organoids were treated by bleomycin (100μM) for 48 hours in vitro and then analyzed.

2022-08-21 | GSE211531 | GEO

Mouse feeder-free alveolar organoids treated by bleomycin

Project description:Mouse feeder-free alveolar organoids treated by bleomycin

| PRJNA870738 | ENA

Organoids-on-a-chip for Colorectal Cancer and in Vitro Screening of Chemotherapeutic Drugs

Project description:The individualized treatment of tumors has always been an urgent problem in clinical practice. Organoids-on-a-chip can reflect the heterogeneity of tumors and is a good model for in vitro anticancer drug screening. In this study, surgical specimens of patients with advanced colorectal cancer will be collected for organoid culture and organoids-on-a- chip. Use organoids-on-a-chip to screen tumor chemotherapy drugs, compare the results of patients’ actual medication regimens, and study the guiding role of organoids in the formulation of precise tumor treatment plans. The investigators will compare the response of organoids to drugs in vitro with the patient’s response to actual chemotherapy and targeted drugs and explore the feasibility and accuracy of organoids-on-a-chip based drug screening for advanced colorectal cancer. The project will establish a screening platform for chemotherapeutic drugs and targeted drugs based on colorectal cancer organoids to quickly and accurately formulate personalized treatment plans for clinical patients.

| 2385953 | ecrin-mdr-crc

Gene expression profile of alveolar macrophages (AM) from bleomycin treated mice.

Project description:Gene expression profile of alveolar macrophages (AM) from bleomycin treated mice.

| PRJNA835498 | ENA

Gene expression in alveolar macrophages between bleomycin–treated wild-type and S1pr2-/- mice.

Project description:We compared mRNA expression in alveolar macrophages between bleomycin–treated wild-type and S1pr2-/- mice, using DNA microarray analysis. In S1pr2-/- macrophages, 398 genes showed decreases to less than 50% of the levels in wild-type macrophages. In contrast, 122 genes showed more than 2.0-fold increases in S1pr2-/- macrophages compared with wild-type macrophages. The downregulated genes in S1pr2-/- mice included the following potentially fibrosis–related genes: profibrotic cytokines, chemokines, and the markers characteristic of classically activated (M1) and alternatively activated (M2) macrophages.

2018-05-30 | GSE85411 | GEO

Gene expression profile of alveolar macrophages (AM) from bleomycin treated mice.

Project description:Osteopontin (OPN, Spp1-/-) is considered detrimental in pulmonary fibrosis. However, effect of OPN produced by AMs during pulmonary fibrosis is not known. We used bulk RNA sequencing to analyze the effect of OPN in AMs from bleomycin treated mice.

2024-03-04 | GSE202348 | GEO

scRNA-seq of Human Alveolar Type 2 Cell Organoids

Project description:Alveolar type 2 (AT2) cells function as stem cells in the adult lung and aid in injury-repair. The current study aimed to understand the signaling events that control differentiation of this therapeutically relevant cell type during human development through differentiation of lung progenitor organoids to AT2 cells and benchmarking against primary AT2 organoids.

2023-06-15 | E-MTAB-12960 | biostudies-arrayexpress

Lungs from bleomycin-treated 129svJ mice

Project description:Profile of gene expression of lungs from bleomycin-treated C129svJ mice. Keywords: parallel sample

2003-06-11 | GSE452 | GEO

Lungs from bleomycin-treated 129svJ mice

Project description:Profile of gene expression of lungs from bleomycin-treated C129svJ mice.

2010-06-05 | E-GEOD-452 | biostudies-arrayexpress